GLP-1 Side Effects, Risks, And Who Should Actually Be Using It | Dr. Christle Guevarra
The Dr. Gabrielle Lyon Show
Dr. Gabrielle Lyon
4.5 • 1.2K Ratings
🗓️ 21 April 2026
⏱️ 83 minutes
🧾️ Download transcript
Summary
We are living through one of the most significant shifts in medicine in generations, and most people don’t fully understand what it means. Dr. Christle Guevarra joins me to zoom out on the entire GLP-1 landscape; from the drug’s origins as a modest diabetes treatment in 2005 to today’s third-generation medications still moving through clinical trials, and what all of it means for the future of obesity, performance, and longevity.
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⏰Timestamps:
00:00 Intro of Show
06:48 Changes in the Fat Loss Landscape
06:54 Engagement in Competitive Powerlifting
11:29 Perspectives on GLP-1 Medication
26:10 Perimenopause Journey
27:13 Topamax
28:03 Urosepsis
30:23 Weight Loss Programming
31:43 Patients' Decision to Take GLP-1
37:44 Risks and Effects on Taking GLP-1
38:10 Pancreatitis
41:40 Fen-Phen (Fenfluramine/phentermine) / Ephedra
45:59 Who Should Not Take GLP-1?
49:24 Proper Nutrition to Support Taking GLP-1
52:14 Recommendation for the New Dietary Guidelines
59:01 Residency and Sports Medicine Fellowship
1:02:38 Are Athletes Recommended to Take GLP-1?
1:08:49 Lack of Randomized, Controlled Trials for Peptides
1:10:38 Key Take-away's from Dr. Christle
1:13:24 Should Women Weigh Themselves?
1:21:02 Should Women Lift Weights?
1:21:55 What's Next for Dr. Christle?
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Transcript
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| 0:00.0 | Throughout various parts of my life, since I can't figure out this whole calories fat loss thing down, |
| 0:08.0 | I am just going to focus on lifting weights and find, you know, joy in taking ownership of the fact that I can lift something heavy. |
| 0:16.0 | It gave me a lot of confidence that I couldn't get from hunger, fat loss, you know, losing weight. |
| 0:23.6 | We are alive at a time that the landscape of medicine is changing. |
| 0:27.6 | JLP ones have been around for a long time, but they haven't been used. |
| 0:31.6 | They have not been FDA approved for weight loss. |
| 0:34.6 | There has never been something more effective than these medications. |
| 0:39.3 | I feel like there's still a lot of a disconnect, |
| 0:42.3 | especially with the way medicine traditionally is set up. |
| 0:45.3 | Sometimes it can get a little hard to help with the behavior change aspect of the |
| 0:51.3 | GLP1 use. |
| 0:52.3 | And so I find that there are still a lot of people who are struggling with |
| 0:56.7 | how do i eat how do i exercise it seems like we could do a little bit better in providing |
| 1:02.1 | that support when it comes to the behavioral change part what are some of the biggest challenges |
| 1:07.6 | that they come in and say they've struggled with when somebody's eating to get in as much fiber to feel satiated and they still don't, I have to wonder, is that |
| 1:17.2 | that Dr. Crystal, welcome the show. |
| 1:28.7 | Thank you so much for having me. |
| 1:30.7 | Now, you're a family physician and you also trained in sports medicine. |
| 1:35.4 | You are educating a lot on the use of GLP-1s, which we are going to talk all about that. |
| 1:40.5 | We're going to talk all about fat loss. |
| 1:42.5 | And you're very interested in muscle preservation |
| 1:45.6 | as well as performance. Correct. That is correct. Take me through what you are seeing right now |
... |
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