Gary Brecka: The SECRET Blood Marker That Could Save Your Life! (pt. 2) : 1248
The Human Upgrade with Dave Asprey
Dave Asprey
4.6 • 7.3K Ratings
🗓️ 6 February 2025
⏱️ 66 minutes
🧾️ Download transcript
Summary
Could the right form of a single vitamin be the difference between thriving and barely surviving?
In this Part 2 conversation, human biologist and longevity expert Gary Brecka reveals the #1 overlooked factor that’s wrecking your health: methylation—your body’s ability to convert nutrients into fuel. If this process fails, your hormones, energy, and even mental health take a nosedive.
Gary and Dave dive deep into the real cause of anxiety, ADHD, and mood disorders, the hidden genetic reason why diets fail, and why Big Pharma isn’t talking about this critical health breakthrough.
Are you unknowingly setting yourself up for disease? What’s the simple fix that can reverse anxiety, gut problems, and even prevent genetic disease? And why is your doctor ignoring one of the biggest markers of longevity?
What You’ll Learn:
• The MTHFR gene mutation—and why it’s quietly affecting millions
• Anxiety, ADHD, and depression—why these disorders start in your cells, not your brain
• The gut-brain connection—how your microbiome controls your mood
• Why your “healthy diet” might be hurting you (and what to eat instead)
• How nutrient deficiencies are passed from mother to child—and how to stop it
• The truth about homocysteine—the blood marker that could predict your lifespan
• Why most people are living at 50% capacity—and how to get your energy back
Resources:
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Gary Brecka’s Website: https://bit.ly/4hlfyti
• Gary Brecka’s YouTube: https://bit.ly/3E3Aaba
• Gary Brecka’s Instagram: https://bit.ly/3PNsgFe
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
• The Mold Movie!: https://moldymovie.com/
SPONSORS:
-BON CHARGE | Go to https://boncharge.com/ and use coupon code DAVE to save 15%.
-Qualia | Go to https://www.qualialife.com/dave15 to get an additional 15% off subscriptions.
Timestamps:
• 00:00 Trailer
• 00:31 What Is Methylation?
• 01:37 MTHFR, Folate & Your Health
• 04:17 How Methylation Affects Disease
• 06:41 Nutrient Deficiencies & Health Risks
• 07:09 Why Blood Work Matters
• 11:44 Homocysteine & Heart Health
• 21:37 Catecholamines & Anxiety
• 34:28 The Link Between Nutrients & Mood
• 34:48 How Catecholamine Ratios Affect Mental Health
• 35:39 Personal Health Struggles & Lessons
• 36:25 The Role of Methylation in Wellness
• 37:57 Methylation & Relationship Dynamics
• 39:49 Hidden Dangers of Mold Toxicity
• 52:55 Hydrogen Water for Health
• 01:01:19 Mitochondria’s Role in Longevity
• 01:02:23 Final Thoughts
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Transcript
Click on a timestamp to play from that location
| 0:00.0 | If I can get you to believe that you have a genetically inherited disease, then I can easily get you to subscribe to a lifetime medication. |
| 0:06.9 | I have not seen in the last seven years a single client that reported suffering from anxiety that did not also have gut issues. |
| 0:14.1 | Not once. |
| 0:15.2 | If you just looked at your methylation pathways only in supplemented for that deficiency and did a basic blood panel, you would be 85% of the way there. |
| 0:22.6 | But the question is, what does your body need? |
| 0:25.6 | You're listening to the human upgrade with Dave Asprey. |
| 0:31.7 | With genetics today, you and I are both very interested in methylation. |
| 0:34.7 | I have MTHFR. |
| 0:35.8 | I've been managing my homocysteine. |
| 0:36.9 | Oh, you're a motherfucker. |
| 0:37.7 | Since I was in my 30s and a COMT issue as well, walk listeners through what methylation is and why it's a big issue. |
| 0:47.2 | Methylation is also called one carbon metabolism. |
| 0:50.5 | It is essentially the best way that I can explain it is it is how the body takes the majority of raw material and convert it into the usable form. |
| 0:59.7 | So I always use the example that we pull crude oil out of the ground. |
| 1:03.9 | But you can't put crude oil into your gas tank because the car doesn't understand that fuel source. |
| 1:09.5 | Crude oil has to be refined into gasoline. Once it's |
| 1:14.3 | refined into gasoline, the car understands that fuel source. This is very true at a cellular |
| 1:18.8 | level in our body. I mean, virtually no compound that we put into our body, virtually nothing, |
| 1:23.7 | no vitamin, mineral, amino acid, protein, carbohydrate, fat, nutrient of any kind, gets used |
| 1:30.2 | in the format that we put it in, right? |
| 1:33.1 | We eat to feed our bacteria, our bacteria eat to feed us. |
| 1:36.6 | Cellular biology is no different when you look at things like, for example, folate or |
... |
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