Tonight, the first winter storm of the season slamming the Northeast while an atmospheric river hammers the West Coast.

Millions feeling the impact as snow blankets in Northeast, some parts seeing up to 20 inches.

The dangerous road conditions, at least one kill.

In Cleveland, the NFL showdown in the snow.

In the West, relentless rain and life-threatening flash flooding,

150 people stranded inside a medical center. All coming as Thanksgiving travel gets off to an early

start. And just breaking tonight, Donald Trump's pick for Treasury Secretary, expected to be

longtime hedge fund manager Scott Bessett, what we're learning.

Also tonight, Matt Gates making an announcement about his political future after he withdrew

as President-elect Trump's Attorney General pick amid sexual misconduct allegations.

And Mr. Trump's new pick for AG, will she have a smoother path?

Plus, the major move in Mr. Trump's hush money case, the judge postponing his sentencing sent for next week, indefinitely.

Will his conviction be tossed out?

The new E. coli alert involving ground beef.

The NBA joining the NFL to warn players after several

burglaries at the homes of star athletes. Are they connected? And space tourists taking a ride

of a lifetime on a blue origin flight to the edge of space and back again.

This is NBC Nightly News with Lester Holt.

Good evening and welcome.

Winter-like weather is creating major impacts across a wide swath of a nation tonight,

from early season snow totals in the Midwest on into the drought-stricken northeast. Heavy snow leaving parts of

Pennsylvania without power, New Jersey, with close to two feet in at least one spot,

...