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NutritionFacts.org Video Podcast

Friday Favorites: What Is Creatine? Its Sarcopenia Benefits and Potential Side Effects?

NutritionFacts.org Video Podcast

Michael Greger, M.D. FACLM

Alternative Health, Health & Fitness, Nutrition

4.8951 Ratings

🗓️ 6 February 2026

⏱️ 9 minutes

🧾️ Download transcript

Summary

When accompanied by a progressive strength-training regimen, 3 grams of creatine a day may improve muscle performance in older adults. A misinterpretation of lab tests may explain concerns over kidney safety with creatine supplementation.

Transcript

Click on a timestamp to play from that location

0:00.0

Creatine is a compound formed naturally in the human body that is primarily involved

0:11.5

in energy production in our muscles and brain.

0:14.5

It's also naturally formed in the bodies of many animals we eat, and so when we eat their

0:18.6

muscles we can also take in some creatine through our diet.

0:21.6

It was named after creus, the Greek word for meat, in which it was first isolated.

0:26.1

We need about two grams a day, so those of meat may get like one gram from their diet,

0:31.5

and their body makes the rest from scratch. There are rare birth defects where you're born

0:35.8

without the ability to make it, in which case

0:38.1

you have to get it all externally through diet.

0:40.3

But otherwise our bodies can make as much as we need to maintain normal concentrations

0:44.5

in our muscles.

0:45.7

When people cut out meat, the amount of creatine floating around their bloodstream goes down, but

0:50.9

the amount in your brain remains the same, because your brain just makes all the

0:54.4

creatine it needs, the level in vegetarian muscles is lower, but that doesn't seem to affect

1:00.7

performance as both vegetarians' meaters respond to creatine supplementation with similar increases

1:05.6

in muscle power output. And if vegetarian muscle creatine was insufficient, then presumably

1:10.5

they would have seen an even

1:11.9

bigger boost.

1:12.9

So basically, when you eat meat, that just means your body doesn't have to make as much.

1:18.2

If creatine muscle content dropped as we grew older, that might help explain age-related muscle

1:23.4

loss, but that doesn't seem to be the case.

1:27.1

Biopsies taken from the muscles of young and old adults show no difference in creatine

...

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