Flip the Switch Up or Down on Autophagy – James Clement : 664
The Human Upgrade with Dave Asprey
Dave Asprey
4.6 • 7.3K Ratings
🗓️ 30 January 2020
⏱️ 67 minutes
🧾️ Download transcript
Summary
In this episode of Bulletproof Radio, I’m hosting a return guest because he’s doing some truly innovative work in the area of human health span and lifespan.
James Clement is a lawyer and entrepreneur turned research scientist who has devoted the last two decades to understanding the science of life extension.
His new book, “The Switch: Ignite Your Metabolism with Intermittent Fasting, Protein Cycling, and Keto,” is the result of years of scientific investigation that started with a curiosity of the human body’s mTOR/autophagy switch. Autophagy is a natural process that recycles and renews damaged cell parts and removes pathogens to keep us healthy. Like a dimmer “switch,” mTOR can turn autophagy up or down. A switch, James says, that’s at the center of nearly every anti-aging drug, nutraceutical, diet, and health choice that we make.
“The purpose of the book is really to go into this molecular biology mechanism inside the cell, which is about as basic as you can get,” James says. “If you're not working these mechanisms properly, then it doesn't matter what your good intentions are, or the practices that you think you're following.”
In our interview James gives practical tips on how we can activate autophagy through different regimens, such as calorie restriction, intermittent fasting, very-low-carb diets, exercise, or supplements. When it’s switched up, autophagy restores our natural metabolism, slows the aging process, and helps fend off diseases from diabetes, to cancer, to heart disease.
James also is known for his Supercentenarian Research Study, which he started in 2010 and received international attention. Through worldwide scientific collaborations and in his own laboratory, his work focuses on advancing biomedical discoveries.
Enjoy the show!
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Transcript
Click on a timestamp to play from that location
| 0:00.0 | What is autophagy? Why do we care about it? |
| 0:04.2 | Well, autophagy itself is a mechanism that allowed bacteria to hunker down when times |
| 0:11.4 | were tough, when nutrients weren't greatly available and to be able to provide some amino |
| 0:19.6 | acids to their system from their own cells. |
| 0:24.6 | So they would break down proteins and organelles into the amino acids so that the cell could |
| 0:31.7 | keep making proteins that allowed it to function. |
| 0:37.4 | You're listening to Bulletproof Radio with Dave Asprey. |
| 0:47.0 | Magnesium is incredibly important for stress, for sleep, and for energy. |
| 0:51.7 | These days, doctors only use high-dose magnesium as a last resort when you're already sick. |
| 0:57.4 | This isn't a good idea because magnesium is involved in 300 different metabolic processes. |
| 1:02.4 | When you're stressed, magnesium burns out of your nervous system, which puts you at |
| 1:05.7 | risk for deficiency, and there are seven different types of magnesium you need to have the |
| 1:11.0 | best health and vitality and energy. |
| 1:13.7 | Getting all of those forms of magnesium in the right doses can upgrade virtually every |
| 1:18.5 | function in your body. |
| 1:20.4 | Even if you need a well-balanced diet, it's a fantasy that you could get enough magnesium |
| 1:25.4 | from food alone because our soil is depleted. |
| 1:28.8 | That's why I like and use magnesium breakthrough by optimizers. |
| 1:32.4 | It's the only product on the market that has all seven types of magnesium in their most |
| 1:37.2 | bio-available forms. |
| 1:38.9 | Make sure you're recovered. |
| 1:39.9 | Go to magbreakthrough.com slash Dave and use code Dave10 for 10% off. |
... |
Please login to see the full transcript.
Disclaimer: The podcast and artwork embedded on this page are from Dave Asprey, and are the property of its owner and not affiliated with or endorsed by Tapesearch.
Generated transcripts are the property of Dave Asprey and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.
Copyright © Tapesearch 2025.