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slash UK slash AI for people. Welcome to the Scientific American podcast Science Talk posted on

January 24th, 2014. I'm Steve Merski. On this episode, our thinking is that the

extracellular matrix, a collagen in these tumors, the abundant collagen in tumors, is a major

contributor to this problem. That's Rakesh Jane, and this problem is the difficulty of getting

drugs to the interior of certain tumors.

Jane is the director of the Edwin L. Steele Laboratory for Tumor Biology in the Radiation Oncology Department of Massachusetts General Hospital and Harvard Medical School.

He is one of only 20 people ever to be elected a member of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.

And he's the author of an article in the February issue of Scientific American about using physics to fight cancer, called an indirect way to tame cancer.

I spoke to him by phone.

Cancer therapy is almost always looked at as a molecular issue. When we hear about a new

cancer drug, it's usually a molecule. And your attempts to deal with cancer obviously are

molecular in nature, but they're within a context of structural considerations

and physics.

That's correct.

Our thinking is that physical forces play an important role in the progression of tumor,

as well as its response of tumor to various treatments.

And these physical forces are manifested in what's called the extracellular matrix?

...