Fighting Antimicrobial Resistance
BBC Inside Science
BBC
4.6 • 1.3K Ratings
🗓️ 9 June 2016
⏱️ 32 minutes
🧾️ Download transcript
Summary
This week we're dedicating the whole programme to one of the biggest threats to humanity. We're already at 700,000 preventable deaths per year as a result of antibiotic resistance, and the O'Neill Report suggests that this will rise to 10 million people per year by 2050. Today, we're focussing on the attempts to discover new antibiotics, and alternative therapies for combating bacterial infection. Firstly, we wanted to know why new antibiotics aren't being produced. Dr Jack Scannell, an expert on the drug development economics, told Adam Rutherford why money has been the main barrier.
Most of the antibiotics we use were discovered in the mid-20th century, but as the threat of drug resistant infections increases, the race is on to find new organisms that make novel medicines. We have only identified a tiny fraction of the microbes living on Earth and are "bioprospecting" for useful ones in wildly different locations. Microbiologist Matt Hutchings has been looking to the oldest farmers in the world - leaf cutter ants.
From exotic locations to under your fridge: Dr Adam Roberts runs a scheme called Swab and Send. It's a citizen science project that asks members of the public to swab a surface and send the sample to him – he'll analyse them to look for the presence of new antibiotic-producing bacteria. We joined in the hunt by swabbing spots around the BBC: Adam's microphone, the Today programme presenters' mics, our tea kitchen's sponge, the revolving entryway doormat, and lastly, the Dalek standing on guard outside the BBC Radio Theatre.
Antibiotics are not the only weapon in the war against bacteria. A hundred years ago, a class of virus that infect and destroy bacteria were discovered. They're called bacteriophages. Phage therapies were used throughout the era of Soviet Russia, and still are in some countries, including Georgia. Phage researcher Prof Martha Clokie told us whether phage therapy might be coming to the UK.
Transcript
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| 0:00.0 | Hello you this is the antibiotic resistant podcast special issue of inside science from BBC Radio 4 |
| 0:05.2 | first broadcasts on the 9th of June 2016 and I'm Adam Rutherford. TV and film references on this program |
| 0:11.6 | include Jerry McGuire Field of Dreams and Doctor Who. |
| 0:14.8 | For more information go to BBC.co.uk. |
| 0:19.2 | UK slash Radio 4. |
| 0:19.5 | Today we're dedicating the whole program to one of the biggest threats that we humans face and it's a problem |
| 0:24.6 | of our own creation. Alexander Fleming first spotted what became penicillin in 1928 and in doing so |
| 0:31.9 | he revolutionized medicine. Innumerable lives. in use in agriculture. In medicine we've been using a small number of antibiotics |
| 0:44.0 | repeatedly and this has resulted in bacteria developing resistance to every |
| 0:48.8 | single one. For a few years we've been hearing about MRSA, methicillin resistant |
| 0:53.7 | Staphylococcus oria, so-called superbugs in hospitals. |
| 0:57.2 | Hand washing practices have changed as a result and that has made a difference. |
| 1:01.0 | But the global situation is not getting much better. |
| 1:04.4 | On the 26th of May this year, reports started coming in of the detection of bacteria that are |
| 1:09.4 | resistant to all antibiotics currently used in medicine as reported here on PBS news. |
| 1:15.0 | For the first time in the US a person has been found to be carrying a strain of |
| 1:19.4 | echolai that's resistant to antibiotics of last resort. |
| 1:24.0 | The Washington Post report of the strain was discovered last month in a 49 year old Pennsylvania woman. |
| 1:28.3 | She was resistant to Coliston and researchers said it, quote, heralds the emergence of a truly pan-drug resistant bacteria. |
| 1:36.3 | Around the same time in May over here a major report was released that has |
| 1:40.5 | attempted to document the scale of this problem. |
| 1:43.3 | Now I'm not prone to scaremongering, but this is pretty chilling. |
... |
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