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As a Woman

Fertility Q&A: Prenatal Vitamins, IVF Labs, Pregnancy Spacing & More

As a Woman

Natalie Crawford

Medicine, Health & Fitness

4.81.1K Ratings

🗓️ 15 March 2026

⏱️ 12 minutes

🧾️ Download transcript

Summary

Dr. Natalie Crawford, board-certified OB-GYN and REI, answers your fertility questions. 1. When taking a prenatal vitamin, how should we interpret the amount of choline listed on the label? If a prenatal lists 300 mg of choline, is that the full amount counted toward the recommended intake, or does it refer to elemental choline? 2. Is sucralose safe to consume while trying to conceive or during pregnancy, or should it be avoided? 3. I’ve heard that high levels of biotin can interfere with certain blood tests. If a prenatal contains 1000 mcg of biotin and someone is going through IVF with frequent lab work, is that amount considered too high? Should they consider switching prenatals? 4. I’m 38, recently diagnosed with PCOS, and have experienced eight miscarriages. I’ve also been told I have a weak and shortened cervix and have already had a vaginal cerclage twice without success. Are there any additional options or treatments that could be considered? 5. I’m 38 and recently had a baby conceived naturally, though it took some time to get pregnant. I know the general recommendation is to wait about 18 months before trying to conceive again, but I’m worried that waiting too long could make it harder to get pregnant because of my age. How should someone balance recommended spacing between pregnancies with age-related fertility considerations? Pre-order Dr. Crawford's debut book, The Fertility Formula, now! https://www.nataliecrawfordmd.com/book Want your questions answered on the next episode? ⁠Ask them here! https://www.nataliecrawfordmd.com/qa-submissions Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

Welcome back to the As a Woman podcast. I'm your host, Dr. Natalie Crawford. And today we're doing one of your favorite episodes. This is Fertility Q&A. I do not know what we are asking. And joining me as Emily Whitlock. Thank you, M. Hi. Of course. Happy to be here. Happy to read you these questions. Thank you to everybody who submitted questions. Okay, starting off strong. We have Amanda. She says, when is Colleen recommended

0:26.9

and is the 450 milligram based on elemental amount or total weight? For example, her prenatal

0:33.1

contains chlorine, but the label states 300 milligrams, but would this be about 120 milligrams

0:41.0

of elemental chlorine? I might be overthinking this. Okay. Amanda, love you. And this is such a

0:46.2

great question. You're overthinking it. So the recommendations that we're giving you in milligrams

0:49.9

is going to be essentially what's written on the bottle. So the true daily recommendation is a little bit higher than this. We are assuming you're getting some choline through your dietary sources. Yes, the highest sources of choline in the diet are going to be animal-based products, meat, eggs, but you can also get it from legumes, beans, tofu, and other sources as well. So the 450 milligrams is the minimum we want you to get in a vitamin

1:11.8

form. And so just look on the vitamin and does it say milligrams, that's what we want it to have.

1:15.8

Perfect. Easy. The second one is also quick and easy. Is sucralose bad when TTC are pregnant?

1:21.9

You know, non-nutrative sugars is what we call this. So it doesn't have any nutritional value

1:27.0

and it is going to be

1:28.3

an artificial sugar have no benefit and potentially only harm. When we look at them independently for

1:34.4

fertility, they do look like they are associated with lower rates of getting pregnant. And of course,

1:40.1

all nutritional data is biased because it is looking at quartiles of use. So people who are using the most versus people who are using none and higher core trial of use looks like it's going to be more harm. This means we want to limit. It doesn't mean never, never, but we definitely want to be in a position where you're not always using it. And I always think when it comes to diet, especially when we start thinking about fertility, getting pregnant,

2:01.0

and when you are pregnant, the things you eat, the majority of them, we want them to have

2:04.8

nutritional value for you. Ideally, there's so many vitamins and nutrients you need when you're

2:09.2

pregnant. Why are we filling some of our caloric need from things that are bringing no

2:13.8

nutritional value? We really, really want to limit those. Michelle says that you, this is another

2:19.3

prenatal question, so that's good. Michelle says that you have mentioned high levels of biotin

2:23.7

can interview with blood tests. She said, would you consider 1,000 MCG in a prenatal too much?

2:29.3

Should I change prenatals because of this? She's currently going through IVF, so blood tests are

2:33.7

obviously very

2:34.3

important to her. A study showed that using biotin over 300 MCGs or micrograms a day was associated

...

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