Fertility Q&A: Miscarriage, Low AMH, PCOS & More

As a Woman

Natalie Crawford

Medicine, Health & Fitness

4.8 • 1.1K Ratings

🗓️ 2 March 2026

⏱️ 19 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Dr. Natalie Crawford, board-certified OB-GYN and REI, answers your fertility questions. I’m 35, had a healthy pregnancy in 2022 followed by three miscarriages, and just found out I have 19% Turner mosaicism on karyotype. If I were your patient, would you recommend moving to IVF with PGT, or continue trying naturally? I’m 32 with an LH/FSH ratio of 2.6 and an AMH of 2.7. The labs were drawn around suspected ovulation. Does this ratio suggest possible PCOS, or could this be a normal mid-cycle finding? I’m 33 and have been trying to conceive for five months. My AMH just came back at 0.057, but the rest of my labs look normal. What would your next steps be, and what are the most common causes of very low AMH at my age? My fiancé uses CBD gummies with trace amounts of THC for chronic pain. We know marijuana can impact fertility, but do CBD products with small amounts of THC meaningfully affect sperm health or fertility outcomes? My partner and I are a same-sex female couple (ages 30 and 32) using donor sperm. We’ve had two unsuccessful IUIs, and I’m about to start a third with letrozole. My workup is normal, but I suspect possible endometriosis. If that’s the case, should we be considering additional evaluation or changing our treatment approach? Pre-order Dr. Crawford's debut book, The Fertility Formula, now! https://www.nataliecrawfordmd.com/book Want your questions answered on the next episode? ⁠Ask them here! https://www.nataliecrawfordmd.com/qa-submissions Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

Click on a timestamp to play from that location

0:00.0	Hi, friends, and welcome back to the As a Woman podcast. I'm your host, Dr. Natalie Crawford. And today is one of our favorite episodes, Fertility Q&A. I am joined by Emily Whitlock. Hi, Ann. Hi. Okay, I don't know what questions we're doing, but these are ones that you guys submitted. So remember, you can go to Natalie CrawfordmD.com. You can go to the podcast
0:21.7	page and submit your own questions there. Ready? Let's go. Okay. The first one is from Leah,
0:28.2	which also I love that you guys, some of you guys put your names, but of course they can be
0:31.7	anonymous if you would like. So Leah is 35. She said that she had a healthy girl in 2022,
0:39.6	which was unfortunately followed by three miscarriages. She said, we don't have any problem getting pregnant, but after doing my karyotype,
0:44.9	I realized that I have 19% Turner Mosaic Syndrome. My doctor said it might or might not be the
0:50.8	reason for my miscarriages. If I were your patient, would you push me towards IVF with PGT?
0:56.1	This is a really good question.
0:57.6	So Turner's Mosaic means that we have two different chromosome lines inside our own chromosomes.
1:04.3	So Turner's syndrome is 45X.
1:06.5	This is associated or this means you just have one X chromosome.
1:10.2	So instead of having two, a normal carotype would be 46X for a woman.
1:15.5	So this means we have cell lines for both, and that's what makes us a mosaic.
1:19.2	Having Turner's syndrome or being a Turner's Mosaic is associated with premature ovarian failure,
1:23.6	in addition to certain complications in birth and having recurrent pregnancy loss can be one of
1:28.7	these things. Because of this, I would definitely talk about, does IVF with PGT make sense? This is
1:34.7	where we can do genetic testing. So we can find out which embryos have a normal karyotype, which ones
1:40.1	might be inheriting the abnormal version. And if this is something that could be preventing us from
1:46.2	getting pregnant, it can make it easier for us to conceive. I've had patients who are turners,
1:51.1	mosaics, many of them go into ovarian failure early. So more than this initial question,
1:55.7	I'm also worried about what is our AMH, how many more kids do we want? How aggressive do we need to be? And I think in this
2:02.2	circumstance, that's a big piece of the discussion as well. The next one says she is 32 years old.
	...

Please login to see the full transcript.

Previous episode | Next episode

Disclaimer: The podcast and artwork embedded on this page are from Natalie Crawford, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of Natalie Crawford and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.