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The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
4.6 • 7.3K Ratings
🗓️ 4 December 2025
⏱️ 62 minutes
🧾️ Download transcript
Summary
If you care about longevity, mitochondria, cardiovascular health, or feeling sharper every day, this episode gives you a clear look at the breakthrough technology that could reshape how supplements are made. Host Dave Asprey talks with Ilan Sobel, CEO of BioHarvest Sciences, about a new way to produce plant compounds at industrial scale without ever growing the plant. Their Botanical Synthesis platform creates highly pure, clinically validated molecules that support blood flow, brain function, metabolic health, and cellular energy with remarkable consistency and little to no environmental waste.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Ilan brings more than two decades of experience in global biotech and consumer health, and under his leadership BioHarvest has grown its flagship product VINIA into one of the fastest growing plant-based supplements in North America. He explains how the company uses plant cell biology and AI guided cultivation to deliver resveratrol, polyphenols, and other high value compounds with superior bioavailability, purity, and measurable clinical effects on arterial dilation, driven by increasing nitric oxide and resulting in improving physical energy, mental alertness and reducing oxidative stress
You will learn:
• Why traditional extraction wastes most of the plant and creates inconsistent supplement quality
• How Botanical Synthesis produces highly bioavailable polyphenols without insecticides, herbacides, fungicides, solvents, or worrying about heavy metal levels.
• Why VINIA increases arterial dilation, improves blood flow, and supports healthy nitric oxide levels
• How reducing ET1 strengthens vascular health in ways typical nitric oxide supplements cannot
• Why better blood flow supports brain performance, mental alertness, and daily physical energy
• What clinical studies show about resveratrol absorption, bioavailability, and 12 hour activity in the bloodstream
• How piceid resveratrol crosses the blood brain barrier to support cognitive function
• Why BioHarvest is developing olive cell compounds like verbascoside for liver fat reduction and cognitive aging
• How future saffron cell technology may influence mood, stress, and cognitive health
• Why this approach offers major advantages for longevity, anti-aging strategies, and high-performance biology
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: plant cell biology, Botanical Synthesis, Vinia polyphenols, piceid resveratrol, nitric oxide production, ET1 reduction, arterial dilation, vascular flexibility, blood flow optimization, brain oxygenation, cognitive alertness, oxidative stress reduction, bioavailable polyphenols, grape cell technology, olive cell compounds, verbascoside research, saffron cell cultivation, clinical blood flow studies, endothelial function, longevity supplementation
**Visti www.vinia.com/Dave - for a generous discount on your next purchase**
Resources:
• VINIA Website: www.vinia.com/Dave
• BioHarvest Website: https://bioharvest.com/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Upgrade Collective: https://www.ourupgradecollective.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen: https://40yearsofzen.com
Timestamps:
0:00 - Trailer
1:30 - How BioHarvest Works
5:23 - Piceid Resveratrol & Clinical Studies
13:37 - Blood Flow & Cardiovascular Benefits
17:08 - Brain Health & Cognitive Effects
20:07 - VINIA Product Line & Pricing
22:33 - Nitric Oxide Mechanism & ET1
26:39 - Chews & Hydration Mix
36:35 - VINIA Heroes Program
41:19 - Olive Cell Technology & Verbascoside
45:13 - Pharmaceutical Implications
51:30 - Saffron Development
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Transcript
Click on a timestamp to play from that location
| 0:00.0 | We've cataloged literally everything that exists out there in the plant kingdom. |
| 0:03.0 | We've had to conquer Mount Everest and back. |
| 0:06.0 | Literally walked up, Mount Everest and back to conquer biological barriers |
| 0:10.0 | to be able to do what we do in the context of bringing these life-changing compounds from plants to consumers by not growing the plant. |
| 0:17.0 | Bioharvest is doing things that make me really, really happy. It's a real pleasure to be here with you, and it took us 17 years to get to this podcast. No one's talked about that on the show before. I've done multiple episodes on... What happens is it gets below the blood-brain barrier, so you have more blood flow, more oxygen, the removal of cellular toxins, and more mental alertness. |
| 0:38.8 | Goodbye, brain fog. |
| 0:39.8 | You're sharp. |
| 0:40.3 | You're on your game. |
| 0:41.2 | Okay. |
| 0:41.5 | Is this going to help with erections? |
| 0:44.6 | You're listening to The Human Upgrade with Dave Asprey. |
| 0:52.9 | This interview is going to be really interesting for you because it's about where plants actually make the compounds that change your biology. |
| 1:01.9 | And it's a problem that no one talks about is that we're basically strip mining jungles and land in search of these amazing plant compounds so we can grind them up, |
| 1:12.3 | throw away 95% of the plant, and then put the rest of it in little capsules to take. |
| 1:17.3 | That's how we do it right now. |
| 1:18.8 | And this isn't really sustainable, and maybe it's not making the purest product. |
| 1:24.3 | In fact, if you look at the studies of what people are buying from Amazon right now, |
| 1:28.1 | you understand what the problem is. So what would happen if we didn't have to do any of that. |
| 1:32.0 | And there's a way to just get the compounds you wanted without any waste whatsoever. And then they |
| 1:36.4 | worked better because you could control their size. Well, the interview today is about how |
| 1:41.8 | that's happening right now. and it's got some really interesting |
| 1:45.6 | effects on our biology when we have really pure, very tiny compounds. |
... |
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