Feb 06 2026 This Week in Cardiology

This Week in Cardiology

Medscape Podcasts

Science, Medicine, Health & Fitness

4.9 • 963 Ratings

🗓️ 6 February 2026

⏱️ 24 minutes

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Summary

Problems with the PREVENT score, a breakthrough in lipid-lowering therapy, a surprising benefit in stroke care, and more thoughts on statins and preventive care of heart disease are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I PREVENT Score

PREVENT Equations in Young Adults https://doi.org/10.1016/j.jacc.2025.12.019
Hospital Readmission Reduction Program for HF

https://pmc.ncbi.nlm.nih.gov/articles/PMC7664458/

II A New Breakthrough in LDL-C Management With an Oral PCSK9 Inhibitor

https://www.medscape.com/viewarticle/time-overcome-pcsk9i-inertia-new-data-future-options-2025a1000wf8

CORALreef Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2511002
CORALreef Outcomes Trial https://clinicaltrials.gov/study/NCT06008756

III A Win for the Factor XI Inhibitor Asundexian – OCEANIC Stroke Trial

https://www.medscape.com/viewarticle/first-clear-win-factor-xia-inhibitors-stroke-reduced-2026a10003t0

OCEANIC-STROKE Slide deck https://clinicaltrialresults.org/wp-content/uploads/2026/02/26-02-02_ISC_OCEANIC-STROKE-primary.pdf
OCEANIC-AF Study Stopped Early https://www.bayer.com/media/en-us/oceanic-af-study-stopped-early-due-to-lack-of-efficacy/

IV Statin Side Effects

Assessment of AEs Attributed to Statins -- Meta-analysis https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01578-8/fulltext

N-of-1 Trial to Assess AEs of Statins https://www.nejm.org/doi/full/10.1056/NEJMc2031173
When to Start a Statin Is a Decision About Preference -- Editorial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.029808

V Heart Disease Statistics

CV Statistics in the US, 2026 https://www.jacc.org/doi/10.1016/j.jacc.2025.12.027

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Questions or feedback, please contact news@medscape.net

Transcript

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0:00.0	You're listening to This Week in Cardiology from the heart.org, Medscape Cardiology.
0:05.7	This podcast is intended for health care professionals only.
0:08.8	Any views expressed are the presenters' own and do not necessarily reflect the views of WebMD or Medscape.
0:14.9	Hi, everyone.
0:16.0	This is John Mandrola from the Heart.org, Medscape Cardiology.
0:20.0	And this is this week in cardiology for February 6, 2026.
0:25.3	This week, some more problems with the prevent-risk equation, a new breakthrough in lipid-lowering therapy,
0:33.2	an even more surprising benefit in stroke care, and some more thoughts on statins and preventive
0:39.5	care of heart disease. So the first topic today is prevent score problems. Now, in the old days,
0:48.4	we used risk scores like Framingham and the pooled cohort equation or PCCE. These weren't perfect, but they were decent.
0:56.9	Recently, key opinion leaders have come up with a new score called the Prevent Score,
1:02.2	which is supposed to be better because it includes 30 to 39-year-olds, and that expands the age range.
1:09.9	It adds heart failure, not just ASCVD. It removes race as a
1:15.9	predictor, supposedly improving equity, and it adds optimal social determinants indexed, and also
1:24.4	includes kidney function. What's more more and I think perhaps the most valuable
1:30.6	or beneficial thing with the prevent score is it's derived from more recent data and therefore
1:36.3	better reflects modern cardiovascular epidemiology. Now finally let's not forget the point of these
1:43.7	risk scores.
1:44.8	The risk scores are used to guide treatment.
1:47.8	Now, instead of treat everyone with, say, a blood pressure of 135 over 90,
1:52.5	the risk scores suggest treatment if a global 10-year risk reaches some set-out threshold.
1:59.5	Now, I go on about this because of a very, very provocative paper published in Jack
	...

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