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Optimal Protein Podcast with Vanessa Spina

Fat Loss without Muscle Loss: The Science of Refeeds, Protein & Recomposition with Dr. Escalante

Optimal Protein Podcast with Vanessa Spina

Vanessa Spina

Fitness, Health & Fitness, Nutrition

4.5 • 758 Ratings

🗓️ 13 October 2025

⏱️ 74 minutes

🧾️ Download transcript

Summary

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Can you really lose fat without losing muscle? Vanessa sits down with Dr. Guillermo Escalante, physique competitor and sports nutrition researcher, to reveal the science of doing exactly that.

Learn how high-protein diets and refeeds can preserve lean mass, reignite a slowed metabolism, and make fat loss more sustainable. Dr. Escalante shares evidence-backed insights from his own research and contest experience on how to optimize protein intake, structure refeeds, and achieve real body recomposition—without the extremes.

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Get delicious high protein meal recipes! Connect with Vanessa on Instagram @ketogenicgirl

Free High-Protein Keto Guide 

Get 20% off on the Tone LUX Crystal Red Light Therapy Mask or the Tone Device breath ketone analyzer at https://ketogenicgirl.com with the code VANESSA

Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast.

Link to join the Facebook group for the podcast

The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.

Transcript

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0:00.0

Welcome to the optimal protein podcast. I'm Vanessa Spina. Hello, my friends. Welcome back to the optimal

0:06.9

protein podcast. I'm your host, Vanessa, and today we are joined by Dr. Guillermo Escalante, an expert in

0:13.5

body recomposition and fat loss. Dr. Escalante is not only a leading researcher in physique science,

0:19.7

he's also a physique competitor

0:21.2

himself. And in this episode, we dive into the real world application of the latest science

0:27.1

on fat loss, protein intake, muscle preservation, and refeeds, blending his firsthand experience

0:33.4

with the peer-reviewed evidence. You'll learn what the latest studies reveal about body recomposition, the science of high-protein diets

0:41.0

during cutting, and how much is truly optimal for preserving lean mass, how trained athletes

0:46.5

can build muscle while losing fat, why refeeds and diet breaks can help you overcome plateaus

0:52.6

and improve adherence and ultimately results,

0:55.9

and Dr. Escalante's personal strategies for achieving extreme leanness while maintaining as much

1:01.4

muscle as possible without wrecking metabolism or hormonal health. This is a master class in

1:07.9

evidence-based physique science from one of the most respected minds in the field.

1:12.2

I can't wait to jump into today's episode and we will get right into it after this quick break.

1:18.1

There is one supplement that I consider absolutely foundational for women and that is creatine.

1:24.5

And I don't say that lightly.

1:26.2

Over the years on this podcast I've interviewed

1:28.2

some of the world's leading protein and muscle metabolism researchers and time

1:33.2

and time again they recommend creatine for women it's one of the most studied

1:38.8

and effective supplements for fat loss body recomposition muscle, muscle building, and even cognition.

1:45.7

The science shows that women naturally have much lower creatine stores than men,

1:50.1

which makes supplementation especially effective.

...

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