FAMILIAR FOES: 49ers Visit Texans and Old Friend DeMeco Ryans in Defensive Battle

Locked On 49ers - Daily Podcast On The San Francisco 49ers

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4.6 • 989 Ratings

🗓️ 23 October 2025

⏱️ 32 minutes

🔗️ Recording | iTunes | RSS

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Summary

John Hickman and Brian Peacock break down the key factors that could decide the game, like the 49ers' ability to overcome injuries, the Texans' impressive defense, and the impact of Mac Jones filling in for Brock Purdy. C.J. Stroud's challenges behind a struggling OL, and offer their predictions for what could be a low-scoring affair.

Transcript

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0:00.0	On this crossover edition, we got the 49ers coming to Houston.
0:04.4	Not quite the D'Amico Ryan's returning home scenario,
0:07.4	but he takes on his former team.
0:09.6	And the San Fran 49ers,
0:11.0	they just find ways to get it done,
0:12.8	which we respect here in Houston.
0:14.3	Because they can't get it done here in Houston.
0:25.3	You are locked on NFL crossover.
0:27.8	Part of the Locked-on Podcast Network.
0:31.3	Your team every day.
0:35.6	Battlerand Nation from Aishtown to your town.
0:39.9	And your town today will be San Fran family, the San Francisco 49 family.
0:44.5	This is the crossover show of the Locked On Texans and the Locked On 49ers podcast.
0:47.7	I'm John Hickman and I am joined by my man.
0:52.5	And it's been a while Brian Peacock reping the 49ers.
0:56.8	It's going to be a fun show because we got to find out just how are you guys getting done with all of the injuries and, you know, can y'all share us your way of life, of living?
1:03.2	Because he just can't get it done, Brian.
1:06.2	Yeah, it's one of the strangest things ever because on one hand,
1:16.7	Kyle Shanahan ticked off the football gods and there's just nonstop injuries.
1:18.5	There's another one that popped up this week.
1:24.8	The only guy that's really given the 49ers a pass rush outside of Nick Bosa is Bryce Huff.
1:26.3	And now Bryce Huff has a hamstring.
	...

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