Extreme Physiology: Everest to Ocean Floor
The Naked Scientists Podcast
Dr Chris Smith
4.6 • 958 Ratings
🗓️ 12 June 2013
⏱️ 56 minutes
🧾️ Download transcript
Summary
Transcript
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| 0:00.0 | The Hello, Hello and this week how we could use bacteria to repair concrete the invisibility |
| 0:24.8 | cloak for your pets and on top of the world what happens to our bodies when we climb |
| 0:29.0 | Mount Everest. If you'd like to get in touch with us here at the naked scientists email Chris at the naked |
| 0:35.0 | scientists dot com tweet at naked scientists or look us up on our Facebook page Facebook |
| 0:40.5 | dot com slash the naked scientist the naked scientist is powered by |
| 0:46.7 | UK fast dot co-dot UK. |
| 0:50.9 | K. For so First though, let's take a look at what's been happening in the world of science with science |
| 0:58.4 | news headlines and kicking off I've got a story all about eyes. One of the big goals of vision restoration is really how we can |
| 1:06.7 | do gene therapy to stop degenerative diseases of the eye which are very common. Things |
| 1:11.5 | like retinal degeneration secondary to |
| 1:13.2 | macular degeneration is a very common condition. Maybe 20-30% of people over the age |
| 1:18.1 | of 60 might be developing this. We think we might be able to prevent some of these |
| 1:22.0 | conditions by using vectors to put genes |
| 1:26.1 | into the cells in the retina that break down during these diseases to protect them. |
| 1:30.8 | One problem though is getting good vectors that can do this. Scientists have had some limited |
| 1:36.4 | success by using viruses including one type of virus called an adenot-associated virus that |
| 1:41.3 | the numbers of cells that they're able to reach like this have been |
| 1:44.2 | fairly limited and they also tend to cause inflammation in the eye when they do this. |
| 1:48.3 | But there's a very encouraging paper it's in science translational medicine this |
| 1:51.9 | week by David Schaefer and his colleagues at the University of California at Berkeley and they have used evolution effectively to help them to do this better. |
| 2:00.0 | So they have taken an adenoc associated virus. They inject this virus into experimental |
| 2:06.6 | animals into their eyes. Then they go in a few days later and they collect the virus just |
... |
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