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The Naked Scientists Podcast

Extreme Physiology: Everest to Ocean Floor

The Naked Scientists Podcast

Dr Chris Smith

Natural Sciences, Science, Science Radio, Naked Scientists, Health & Fitness, Engineering, Medicine, Technology, Life Sciences

4.6958 Ratings

🗓️ 12 June 2013

⏱️ 56 minutes

🧾️ Download transcript

Summary

How can an ascent to the top of Everest help to save lives in intensive care? This week we're exploring physiology at the extremes: altitude, depth and cold. How does the human body adapt and cope under these conditions? Also, news of improved gene therapy techniques for sight-loss disorders, when do babies become sympathetic, how to cloak your cat (or goldfish), and have scientists discovered the remains of the Tunguska meteorite that smashed into Siberia in 1908? Like this podcast? Please help us by supporting the Naked Scientists

Transcript

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0:00.0

The Hello, Hello and this week how we could use bacteria to repair concrete the invisibility

0:24.8

cloak for your pets and on top of the world what happens to our bodies when we climb

0:29.0

Mount Everest. If you'd like to get in touch with us here at the naked scientists email Chris at the naked

0:35.0

scientists dot com tweet at naked scientists or look us up on our Facebook page Facebook

0:40.5

dot com slash the naked scientist the naked scientist is powered by

0:46.7

UK fast dot co-dot UK.

0:50.9

K. For so First though, let's take a look at what's been happening in the world of science with science

0:58.4

news headlines and kicking off I've got a story all about eyes. One of the big goals of vision restoration is really how we can

1:06.7

do gene therapy to stop degenerative diseases of the eye which are very common. Things

1:11.5

like retinal degeneration secondary to

1:13.2

macular degeneration is a very common condition. Maybe 20-30% of people over the age

1:18.1

of 60 might be developing this. We think we might be able to prevent some of these

1:22.0

conditions by using vectors to put genes

1:26.1

into the cells in the retina that break down during these diseases to protect them.

1:30.8

One problem though is getting good vectors that can do this. Scientists have had some limited

1:36.4

success by using viruses including one type of virus called an adenot-associated virus that

1:41.3

the numbers of cells that they're able to reach like this have been

1:44.2

fairly limited and they also tend to cause inflammation in the eye when they do this.

1:48.3

But there's a very encouraging paper it's in science translational medicine this

1:51.9

week by David Schaefer and his colleagues at the University of California at Berkeley and they have used evolution effectively to help them to do this better.

2:00.0

So they have taken an adenoc associated virus. They inject this virus into experimental

2:06.6

animals into their eyes. Then they go in a few days later and they collect the virus just

...

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