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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Exenatide Pharmacology Podcast

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 6 April 2023

⏱️ 15 minutes

🧾️ Download transcript

Summary

On this podcast episode, I discuss exenatide pharmacology, adverse effects, drug interactions, and much more!



Exenatide has an immediate release formulation (Byetta) and a long acting formulation (Bydureon). I discuss the differences in this podcast episode.



Byetta use has fallen out of favor due to frequent dosing, patient inconvenience and needing to time the dose 60 minutes prior to meals.



I discuss the risk of pancreatitis related to GLP-1 agonists like exenatide in this podcast episode.

Transcript

Click on a timestamp to play from that location

0:00.0

Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist, Derek Christensen.

0:05.7

Thank you so much for listening today. As always, go check out real-life pharmacology.com. We've got the free

0:12.0

31-page PDF on the top 200 drugs. That's a no-brainer. Simply an email. We'll get you access to that.

0:20.2

Do that at real-life pharmacology.com also flipping

0:25.6

pharmacology flashcards new product just put out you can find that on amazon so a great way

0:32.1

to support this podcast help keep it free and available for all those to benefit from.

0:37.9

So again, flipping pharmacology flashcards, you can go check those out on Amazon.

0:43.5

All right, let's get into the drug of the day today, and that is exenetide.

0:48.4

Brand name of this medication is bieta or by durium.

0:53.7

Now, if you haven't been in practice really long or your student,

0:57.7

you're probably not terribly familiar with Bietta

1:01.1

or you've probably never seen it.

1:03.4

I can tell you from my experience,

1:05.3

I can't recall the last time I've seen Biaetta,

1:09.7

but I did see it several years ago.

1:14.2

So, long story short, the big issue with Bayetta is dosing.

1:20.3

So, bieta is actually a sub-Q injection twice a day.

1:25.5

So as you could imagine, comparing that to by Durian and some of the other

1:31.5

GOP-1 agonus, that's a problem and a patient issue where they have to give an injection

1:38.9

twice a day versus where they can give an injection just once weekly. So just a little background on Bayetta, five micrograms twice a day, can go up to one

1:51.0

microgram twice a day after a month.

1:54.2

The other issue is that dose actually has to be given within 60 minutes or 60 minutes prior to morning and or evening

...

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