Everything You Need to Know About GLP-1s
The Thick Thighs Save Lives Podcast
Constantly Varied Gear
4.9 • 724 Ratings
🗓️ 5 May 2026
⏱️ 43 minutes
🧾️ Download transcript
Summary
GLP-1 medications like Ozempic and Wegovy are everywhere right now. But what do they actually do? And who are they for?
Today we’re joined by Dr. Spencer Nadolsky, also known as “The Doc Who Lifts.” He’s an obesity and lipid specialist physician, founder of Vineyard and ChefRX, and co-host of the Docs Who Lift podcast.
Dr. Nadolsky breaks down the science, myths, and real-life impact of GLP-1s, including:
What it feels like to be on GLP-1s
Expected weight loss results
Comparison of weight loss drugs: Ozempic vs Wegovy vs Zepbound
Side effects
What happens when you stop taking them
Are they ruining metabolism? Muscle? Bones? Relationships!?
Are GLP-1s the solution to obesity?
Tune in and find out.
Links:
IG: https://www.instagram.com/drnadolsky/
Vineyard: https://joinvineyard.com/
ChefRX: https://orders.chefrx.co/get-started
The Docs Who Lift Podcast: https://drspencer.com/podcast/
(00:00:00) Welcome to the podcast. Meet Dr. Nadolsky.(00:06:03) Simple explanation GLP-1s
(00:08:23) Who GLP-1s are for
(00:11:26) Ozempic vs Wegovy vs Zepbound
(00:12:48) Expected weight loss results
(00:15:06) Side effects explained
(00:23:42) What it feels like to be on GLP-1s
(00:27:16) Why people are so emotional about GLP-1s
(00:33:27) Are GLP-1s the solution to obesity?
(00:39:18) The #1 thing everyone should do for their health
(00:42:35) Where to find Dr. Nadolsky
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Transcript
Click on a timestamp to play from that location
| 0:00.0 | The big thing that people notice is that they no longer think intrusively about food all day long. |
| 0:06.1 | So they didn't realize that their whole life revolved around thinking around food. |
| 0:09.6 | Yeah, I strongly recommend resistance training to all of our patients to minimize bone loss and muscle loss. |
| 0:16.0 | The resistance is by far the most important. |
| 0:18.1 | Yeah, I always say don't compare your weight loss as someone else. |
| 0:21.2 | Everybody responds differently. People, they want to squash their appetite. You don't want to |
| 0:26.0 | completely eliminate the appetite. You want to normalize the appetite. You still need to eat and |
| 0:30.4 | fuel your body and get enough nutrients. On average, there are people that respond really well that |
| 0:34.9 | will lose a lot more. And there's some people that are low |
| 0:37.9 | responders or hypo responders, they'll lose less. But in general, we're looking at about 0% total body |
| 0:43.3 | weight loss. All right, guys, hot topic for you today. GLP ones are what everyone's talking about. |
| 0:48.8 | So we decided to cover the dues and don'ts, misbusting. What is going on with these? |
| 0:54.6 | Our special guest, Dr. Spencer Nidalcate, brings over a decade of expertise in obesity |
| 0:58.9 | medicine. |
| 1:00.0 | And since becoming a doctor, he's helped thousands of patients lose weight and improve their |
| 1:04.6 | quality of life through innovative healthcare deliveries. |
| 1:07.2 | So let's hear about GLP ones, the do's and don'ts, miss busted. |
| 1:10.9 | Hope you guys enjoy this episode. |
| 1:16.7 | Hey guys, and welcome back to the Thick Thigh Save Lives podcast. |
| 1:20.1 | I'm Kelsey, and I'm joined today with a special guest, Dr. Spencer Nodalski. |
| 1:24.4 | Welcome. |
| 1:25.5 | Thanks for having me on. |
... |
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