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🗓️ 1 January 2026
⏱️ 40 minutes
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| 0:00.0 | Welcome to Huberman Lab Essentials, where we revisit past episodes for the most potent and actionable science-based tools for mental health, physical health, and performance. |
| 0:11.3 | I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine. |
| 0:17.2 | And now, from my discussion with Dr. Rhonda Patrick. |
| 0:20.6 | Rhonda, welcome. I am so excited to be here having a conversation with you. Rhonda Patrick. Rhonda, welcome. |
| 0:21.6 | I am so excited to be here having a conversation with you. |
| 0:24.2 | Thank you. |
| 0:24.9 | I have so many questions, but I want to start off with a kind of a new but old theme that you're very familiar with. |
| 0:33.8 | So temperature is a powerful stimulus, as we know for biology. |
| 0:38.3 | And you've covered a lot of material related to the utility of cold, but also the utility of heat. |
| 0:45.3 | And as I learn more and more from your content and from the various papers, it seems that cold can stimulate a number of things like increases in metabolism, brown fat, et cetera, et cetera, |
| 0:56.3 | but heat seems to be able to do a lot of the same things. |
| 0:59.9 | And I wonder whether or not the discomfort of cold, deliberate cold exposure, and the discomfort of heat |
| 1:06.3 | might be anchoring to the same pathway. |
| 1:09.7 | So would you mind sharing with us a little bit about |
| 1:11.8 | what happens when we get into a cold environment on purpose and what happens when we get |
| 1:17.4 | into a hot environment on purpose? Let's take a step back. And I think you brought up a really |
| 1:22.1 | important point here. You know, we evolved to intermittently challenge ourselves. And before we had Instacart where you could |
| 1:30.1 | basically just get your food delivered to you, we were out hunting, gathering, we were moving, |
| 1:35.7 | and we had to be physically fit. You couldn't, you know, catch your prey if you were a sedentary |
| 1:40.0 | slob, right? Physical activity was a part of everyday life. And caloric restriction or in a minute |
| 1:47.2 | fasting was also a part of it. This is another type of challenge. You know, we, we didn't always, |
| 1:52.6 | you know, have a prey that we caught or maybe temperatures were such that, you know, there was |
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