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STEM-Talk

Episode 61: Chris McCurdy discusses kratom and the opioid crisis

STEM-Talk

Dawn Kernagis and Ken Ford

Health & Fitness, Nutrition, Science, Natural Sciences, Alternative Health

4.6 • 694 Ratings

🗓️ 10 April 2018

⏱️ 63 minutes

🧾️ Download transcript

Summary

More than 90 Americans a day are dying from opioid abuse. Today’s guest, Dr. Christopher McCurdy, is at the forefront of research designed to help the U.S. deal with this drug overdose crisis. Chris is a medicinal chemist and behavioral pharmacologist at the University of Florida who is internationally known as an expert on kratom, a botanical mixture that has been shown to help people struggling with addiction. He recently became president of the American Association of Pharmaceutical Scientists, and has spent his career focusing on the design, synthesis and development of drugs to treat pain and drug abuse. Chris earned his bachelor of science degree in pharmacy from Ohio Northern University, and a Ph.D. in medicinal chemistry from the University of Georgia College of Pharmacy in 1998. He did his postdoctoral work at the University of Minnesota where he focused on opiate chemistry in relation to drug abuse and drug addiction. He joined the faculty at the University of Mississippi in 2001 where much of his research was successful in discovering unique and selective tools for sigma receptors, NPFF receptors and opioid receptors. Dr. McCurdy accepted a post as a professor of medicinal chemistry at Florida in 2017 and became the director of the university’s Translational Drug Development Core.  Links:  Christopher McCurdy UF faculty page: http://pharmacy.ufl.edu/faculty/christopher-mccurdy/ American Association of Pharmaceutical Scientists: https://www.aaps.org/home Translational Drug Development Core: https://www.ctsi.ufl.edu/research/laboratory-services/translational-drug-development-core/  Suspected Adulteration of Commercial Kratom Products with Hydroxymitragyine: https://www.ncbi.nlm.nih.gov/pubmed/27752985 Self-treatment of Opioid Withdrawal Using Kratom: https://www.ncbi.nlm.nih.gov/pubmed/18482427 Herbal Medicines for the Management of Opioid Addiction: https://www.ncbi.nlm.nih.gov/pubmed/22133323 Show notes:  2:58: Ken opens by asking Chris if he ever dreamed of becoming a professional athlete as a result of growing up in Pittsburg during the hay-day of the Stealers and the Pirates. 3:28: Dawn mentions that Chris’s father was a pharmacist, and his mother, a science teacher. She further mentions that in addition to being interested in sports, that Chris also was interested in science, and she asks what role his parents played in that. 4:45: Dawn mentions that Chris moved to a suburb of Youngstown Ohio just as he was starting high school. Chris talks about playing basketball, being part of a competitive swim team, and his reputation as a fairly straight-laced kid. 5:27: Ken mentions that Chris headed to Ohio Northern University after he graduated from high-school and initially pursued a double major in pharmacy and music. Ken asks what prompted that particular combination. 6:39: Ken talks about how at Ohio Northern, Chris’s first real mentor in science noted his talent for research, and suggested that Chris should head to the University of Georgia for the summer to get acquainted with research. Chris talks about how that eventually led to him attend Georgia for his doctorate. 10:39: Ken asks Chris to talk about his doctoral research into Native American Tobacco. 13:28: Dawn comments on how there weren’t too many post-doc opportunities available at the time he finished his studies at Georgia, but that she understands there is an apparent pattern in his life of being at the right place at the right time. She asks if it was this pattern that lead him to the University of Minnesota. 17:05: Dawn inquires as to what got Chris interested in working on the natural product called Salvinorin A (Magic Mint), and what became of that research. 20:40: Dawn mentions that because of his work on salvia divinorum, Chris was invited by the National Institute of Drug Abuse to give a talk in 2004, which is where he first learned about kratom.

Transcript

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0:00.0

Welcome to STEM Talk.

0:02.0

STEM Talk.

0:03.0

STEM Talk.

0:04.0

STEM Talk.

0:05.0

Welcome to STEM Talk, where we introduce you to fascinating people who passionately

0:10.0

inhabit the scientific and technical frontiers of our society.

0:14.0

Hi, I'm your host, Don Kornegas, and joining me to introduce today's podcast as the Man Behind the Curtain Dr. Ken Ford,

0:20.0

IHMC's director and

0:21.7

chairman of the double secret selection committee that selects all the guests who appear on STEM

0:25.7

Talk.

0:26.7

Hi, Don. Great to be here today.

0:29.5

So the U.S. is in the midst of the deadliest drug overdose crisis in its history.

0:34.8

More than 90 people die every day from opiate abuse.

0:44.7

Today's guest is Dr. Christopher McCurdy, whose research focuses on the design, synthesis,

0:50.7

and development of drugs to treat pain and drug abuse. He is an internationally recognized expert on Kratom, a tropical evergreen tree in the coffee family native to

0:56.5

Southeast Asia. Many have reported using Kratom to wean themselves from opiates and also as a way of

1:03.5

dealing with chronic pain. There is much confusion, swirling around Kratom, and not much

1:10.1

solid scientific research. As our listeners

1:12.8

will hear, Dr. McCurdy is the exception. And this episode is an opportunity to hear the

1:19.7

latest science on this topic. But before we get to today's interview with Chris, we have some

1:25.1

housekeeping to take care of. First, we really

1:27.5

appreciate all of you who have subscribed to STEM Talk, and we are especially appreciative

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