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Naturally Nourished

Episode 486: Protein Sparing Modified Fasting

Naturally Nourished

Ali Miller RD

Nutrition, Health & Fitness:nutrition, Health & Fitness

4.7668 Ratings

🗓️ 16 March 2026

⏱️ 52 minutes

🧾️ Download transcript

Summary

In this episode, we’re diving into the hot topic of protein sparing modified fasting (PSMF) and why short, strategic “3-day sprints” can be a powerful metabolic reset. Ali shares how these brief hypocaloric phases may help accelerate body fat loss while supporting anti-inflammatory processes and increasing autophagy, the body’s natural cellular cleanup system.  The literature consistently shows that most diets fail long term, with weight regain common within five years, and often much sooner with more aggressive interventions like GLP-1 medications or surgical approaches. In this conversation we explore who may benefit from protein sparing fasts, who should avoid them, where supplements fit in and how to implement this strategy. We also discuss research on autophagy. Also in this episode:  Beat the Bloat FREE Masterclass 4/7 Beat the Bloat Program starts 4/21 What is a protein sparing modified fast? A Systematic Review of Evidence on the Use of Very Low Calorie Diets in People with Diabetes - PubMed The protein-sparing modified fast for obese patients with type 2 diabetes What does a day of fasting this way look like? A protein sparing fast can be broken into 1 meal and 2 snacks or 2 meals or even 3 meals, but I typically do: Coffee with Pure Collagen and ½ scoop Whey Protect with 1 Tbsp heavy cream (26g protein, 150 cal) 1 jar FOND (15g protein 60 cal) 6oz filet of wild salmon (300 cal 33g pro) 1 jar of FOND  (15g protein 60 cal)  Naturally Nourished Teas Thoughts on dry fasting or water fasting  Does protein disrupt autophagy? A high protein meal does not change autophagy in human blood In Defense of Protein Effects Of Oral Glutamine on Inflammatory and Autophagy Responses in Cancer Patients Treated With Abdominal Radiotherapy: A Pilot Randomized Trial Bone Broth benefits Glycine Relieves Intestinal Injury by Maintaining mTOR Signaling and Suppressing AMPK, TLR4, and NOD Signaling in Weaned Piglets after Lipopolysaccharide Challenge Curcumin induces autophagy, inhibits proliferation and invasion by downregulating AKT/mTOR signaling pathway in human melanoma cells - PubMed Who should consider PSMF and who should not?  What supplements support PSMF? Detox Packs Multidefense  Relax and Regulate Berberine Boost Calm and Clear GabaCalm

Transcript

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0:00.0

Welcome to the Naturally Nourished Podcast that delivers cutting-edge food is medicine solutions for optimal health.

0:12.8

Ali Miller is a nutrition expert sought up by the media in America's top medical institutes

0:18.3

for her revolutionary functional medicine interventions.

0:22.6

From disease treatment to prevention, every episode will empower you with ways to put yourself

0:28.3

back in control of your health. Please know, the topics discussed are for educational purposes

0:35.1

only. Now welcome, Integrative Dietitians, Allie Miller, and her co-host, Becky You.

0:42.9

Welcome to the Naturally Nourished Podcast. Today, we are taking on a hot topic, protein sparing fasting.

0:51.3

If you've been watching Allie on social media, her recent stories and shares have all been

0:58.8

about this approach of hypokaloric restriction and getting the benefits of fasting while

1:06.2

not doing like, you know, a 24 hour or water fast, but doing more of a protein sparing fast. So in today's

1:13.0

episode, we're going to unpack the benefits of a hypocholaric fast, thoughts on prolonged fasting,

1:18.9

thoughts on Omad and whether that has changed at all, and who's a good candidate for a protein

1:25.3

sparing fast? Yes, I have been loving the freedom that I'm getting with doing these three-day

1:33.1

hypoloric protein sparing sprints.

1:36.3

We'll talk in today's episode about doing an approach to protein sparing fasting for

1:41.7

lengths of six to 12 weeks without these like tight sprint cycles

1:46.7

or employing protein sparing fasting like I'm doing integrated within a food as medicine

1:53.4

keto protocol to be a little bit more gentle. Like Becky said, we'll talk about who's a good

1:59.0

candidate and who shouldn't fast or who this

2:01.9

might not be a fit for. I've been sharing some of my intake days over at my new Instagram

2:08.8

handle, which is at Naturally Nourished Allie Miller R.D. So be sure to follow over there. I really got on this kick without intention. I had started the

2:22.6

Beat the Bloke cleanse and I kicked that off on January 5th along with a 10 day detox. And as I was

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