Episode 154: Is Seed Based Cultivation the Future of Cannabis? - with Dr. Matthew Indest

Cannabis Cultivation and Science Podcast

Tad Hussey.

Cannabis, Gardening, Natural Sciences, Cultivation, Leisure, Science, Home & Garden, Marijuana, Weed, Growing, Organics, Grow

4.7 • 716 Ratings

🗓️ 10 December 2025

⏱️ 86 minutes

🔗️ Recording | iTunes | RSS

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Summary

Seed-grown cannabis has been talked about for years, but most commercial growers still lean on clones for consistency. In this episode, Dr. Matthew Indest and I dig into whether the industry is finally approaching a true shift. We unpack the science, the barriers, and the practical realities: genetic stability, uniformity, agronomic traits, pathogen concerns, breeding strategies, and the economics behind large-scale seed adoption. Dr. Indest brings a rare mix of rigorous plant science and real-world cannabis experience. If you’ve wondered whether seed-based cultivation can match or even outperform clonal systems — or what breeders actually need to deliver for that future to happen — this episode lays it out clearly.

Transcript

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0:00.0	Welcome to the Cannabis Cautilance Podcast. I'm your host, Tad Hussey of Kiss Organics.
0:23.2	This is the podcast where we discuss the cutting edge of growing from a science-based perspective
0:27.5	and drawn top experts from around the industry to share their wisdom and knowledge.
0:32.1	Just a friendly reminder that we also have a Patreon channel with a free seven-day trial and tiers as low as $5 a month.
0:39.0	We do book club, special cultivation tips and tricks, monthly video hangouts to connect and share
0:44.1	your grow, and even give out seed packs and other gifts at certain tier levels.
0:48.3	I share my personal grow on there, as well as a private Discord channel for members.
0:52.5	Your support of Patreon or sourcing your products
0:54.8	through Kiss Organics is what supports the podcast and I really appreciate it. Now on to the show.
1:00.2	My guest this week is Dr. Matthew Indest. Matthew is a plant scientist, breeder, and cultivation
1:05.7	strategist with over a decade of experience working at the intersection of plant genetics,
1:10.7	agronomy,
1:11.3	and commercial cannabis production. He has led large-scale breeding and cultivation programs
1:16.1	across indoor, greenhouse, and outdoor systems for cannabis operators, with a focus on developing
1:22.1	high-performing cultivars, improving plant health, and integrating data-driven systems for consistent yield and quality.
1:29.0	With a PhD in plant science and a hands-on approach to solving real-world cultivation challenges,
1:34.8	Dr. Indus brings both scientific rigor and practical insight to applied research.
1:39.6	His consulting and advisory work emphasized the application of scientific research to commercial
1:44.4	cultivation systems, bridging the gap between academic discovery and industry adoption.
1:49.8	Now on to the show.
1:51.1	Hey Matthew, thanks for coming on the show today.
1:54.5	Yeah, good to be here, Tad.
	...

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