Oh, wow, oh, oh, wow, oh, wow, oh, wow.

Oh, wow.

Oh, my. Hello, you're listening to The Science of Everything podcast, episode 152, obesity, diabetes, and hypertension.

I'm your host, James Fodor.

So today we are going to continue from the previous episode, diet and nutrition, and talk about

some of the consequences of malnutrition, specifically overnutrition, and look at what's

sometimes called metabolic syndrome.

This is a clustering of multiple different medical conditions, including obesity, high blood pressure,

high blood sugar, and high blood lipids. This is going to be a bit of a bulky, intense episode,

because there's a lot to get through, and the biology here is a bit complicated, and it's still

not fully understood. But we'll do our best and in particular the way I'll talk about

this is I'll first outline the basic biological processes that are relevant to metabolic syndrome,

particularly talking about the role of blood lipids, blood glucose and blood pressure and some of the

systems that regulate

those. And then I'll talk about how those systems go wrong, or some of the things that happen

in metabolic syndrome, in obesity, and high blood pressure, and diabetes, including the

effects of abdominal obesity and how that affects other body systems, how lipid, metabolism, insulin, and

blood pressure become dysregulated. And then finally we'll talk about the health effects of

these underlying dysregulations. So the idea is to sort of gradually build up from basic

mechanisms and core biological systems to the actual health

effects that those have.

And this is always a tricky topic to discuss because these different systems are so interconnected

...