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The Science of Everything Podcast

Episode 138: Biochemistry and Metabolism

The Science of Everything Podcast

James Fodor

Natural Sciences, Science, Social Sciences

4.8750 Ratings

🗓️ 31 August 2023

⏱️ 59 minutes

🧾️ Download transcript

Summary

A discussion of the metabolic pathways involved in breaking down proteins, carbohydrates, and lipids into simple components, extracting their energy, and building back up into more complex components needed for bodily function. We cover glycolysis, the citric acid cycle, lipolysis, beta oxidation, amino acid deamination, gluconeogenesis, fatty acid synthesis, and amino acid synthesis. Our overall focus is on the central role of acetyl-CoA and how the different metabolic pathways interact and intersect. Recommended pre-listening is Episode 18: Biochemistry Basics and Episode 75: Cellular Respiration. If you enjoyed the podcast please consider supporting the show by making a PayPal donation or becoming a Patreon supporter. https://www.patreon.com/jamesfodor https://www.paypal.me/ScienceofEverything

Transcript

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0:00.0

Oh, wow, oh, oh, wow, oh, wow, oh, wow.

0:13.0

Oh, wow.

0:15.0

Oh, my. Hello, you're listening to the Science of Everything podcast, episode 138, biochemistry and metabolism.

0:41.7

I'm your host, James Fodor.

0:43.3

So in this episode, we're going to discuss biochemistry and human metabolism.

0:48.1

And as part of that, we're going to look at the three major macromolecules or types of nutrients that are metabolized in the human body,

0:56.6

proteins, carbohydrates, and lipids.

0:59.2

Recommended pre-listening for this episode is episode 18, biochemistry basics, as well as episode 75 on cellular respiration.

1:07.2

We build on some of the material developed there, so I strongly recommend you check those out before

1:11.2

listening to this one. What we're going to talk about in this episode, as I've said, are the three

1:15.6

major macronutrient molecules, and in particular we're going to discuss how each of them

1:20.4

is broken down into smaller constituents, and then how each of them can be built up again

1:25.3

to form new versions of proteins and carbohydrates and lipids that are needed throughout the body.

1:30.3

So these two types of processes are known as catabolic and anabolic. So catabolic is breaking down and anabolic is building up.

1:38.3

And we'll look at each of those processes for each of our three major types of macromolecules.

1:44.5

So let's get started by first giving a quick introduction to what metabolism is

1:48.5

before we go through all of the three different types of molecules.

1:51.5

So metabolism is the set of chemical reactions that occurs in organisms that sustains life.

1:57.5

So the three main functions of metabolism are converting energy from food into a form that's

2:02.9

available to run cellular processes, converting food to building blocks for structural and functional

2:09.4

components of the body. So those are proteins, lipids, and nucleic acids and so forth. And finally,

2:14.2

eliminating metabolic wastes. I'll talk about eliminating wastes in a different episode.

...

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