Episode 12: Dale Bredesen discusses the metabolic factors underlying Alzheimer’s Disease

STEM-Talk

Dawn Kernagis and Ken Ford

Natural Sciences, Alternative Health, Science, Health & Fitness, Nutrition

4.7 • 706 Ratings

🗓️ 24 May 2016

⏱️ 86 minutes

🔗️ Recording | iTunes | RSS

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Summary

Dr. Dale Bredesen says Alzheimer’s Disease is the third leading cause of death in the United States. Dr. Bredesen has developed a novel therapeutic approach that addresses the underlying metabolic changes leading to development of the disease. Dr. Bredesen’s approach, called MEND (metabolic enhancement for neurodegeneration) helped a 65-year-old woman recover her functional memory, after her first physician had written her off as bound to the same demise of her mother, who suffered and died from Alzheimer’s Disease. Bredesen shares these and other insights in this episode of STEM-Talk, where he and host Dawn Kernagis engage in a rich and thought-provoking conversation about the future of treating neurodegenerative and other diseases. Bredesen has been on the faculty at UCSF, UCSD. Currently, he divides his time between UCLA and the Buck Institute for Research on Aging, of which he is founder and CEO: http://buckinstitute.org/bredesenLab

Transcript

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0:00.0	I don't always listen to podcasts, but when I do, I listen to STEM talk, interviewing the most interesting people in the world of science and technology.
0:14.5	Stay curious, my friends.
0:19.8	Welcome to STEM Talk. Stem Talk, STEM Talk, STEM Talk, STEM Talk.
0:21.1	Stem Talk.
0:22.6	Stem Talk.
0:23.6	Stem talk.
0:24.6	Stem Talk, where we introduce you to fascinating people who passionately inhabit the scientific and technical frontiers of our society.
0:33.6	Hi, I'm your host, Don Cornegas. And today we have Dr. Dale Bredison with us, a physician and scientist who is conducting extraordinarily innovative research on Alzheimer's disease.
0:43.4	Also joining us today is Dr. Ken Ford, IHMC's director and chairman of the double secret selection committee that selects all the guests to appear on STEM Talk.
0:51.7	Hi, Don. Good to be here with you.
0:54.0	So Dr. Bredison is an internationally recognized expert in the mechanisms of neurodegenerative diseases,
0:59.7	such as Alzheimer's disease.
1:01.4	The continuing failure to find effective treatments for Alzheimer's disease has highlighted the critical
1:06.0	need for a deeper understanding of the probable multiple causes of Alzheimer's disease.
1:12.7	Dr. Bredison's innovative work has led to new therapeutic approaches to treatment of this devastating disease.
1:18.0	Dale's group has found evidence that Alzheimer's disease stems from an imbalance in nerve cell
1:23.7	signaling. In the normal brain, specific signals foster nerve connections and memory
1:29.3	making, while balancing signals support memory breaking, allowing irrelevant information to be forgotten.
1:36.3	But in Alzheimer's disease, the balance of these opposing signals is disturbed.
1:43.3	Nerve connections are suppressed and memories are lost.
1:47.8	And this model is actually contrary to popular belief that Alzheimer's is a disease
1:52.0	caused primarily by the accumulation of plaques in the brain.
	...

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