Ep. 527 Ep. 527 HRT Changes Your Lipids More Than You Think – The Surprising Truth About Menopause & Heart Disease with Dr. Thomas Dayspring |Women's Cardiovascular Health

Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

Cynthia Thurlow

Alternative Health, Nutrition, Science, Life Sciences, Health & Fitness

4.8 • 1K Ratings

🗓️ 10 December 2025

⏱️ 64 minutes

🔗️ Recording | iTunes | RSS

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Summary

I am honored to have Dr. Tom Dayspring join me again today for another AMA session. He and I have done eight podcasts before, and this is a continuation of our last Ask Me Anything episode. Dr Dayspring is an esteemed expert on internal medicine and clinical lipidology. He is likely one of the most influential worldwide lipid experts, so I am thrilled to have him back with me to dive into various topics related to listener questions, including the impact of hormone replacement therapy on lipid changes, methods of administration, and why bioidentical hormone replacement therapy is preferable for managing both menopausal symptoms and lipid health. We discuss medications, including PCSK9 inhibitors and GLP-1s, as well as intermittent fasting, lipids, and cardiovascular disease risk. We also examine how heart disease develops gradually, over time, the impact of stress and lifestyle, and Dr. Dayspring shares the labs he recommends beyond traditional lipids, ApoB, and LpA. In our discussion, Dr. Dayspring noted that he was not in a position to speak about GLP-1 therapies or microdosing. Since I received many questions from listeners on those topics, I will host a future solo AMA to address some of their concerns. Today's conversation with Dr. Tom Dayspring is truly invaluable, and I trust you will walk away with valuable insights you can share with your healthcare providers. We created a PDF - cynthiathurlow.com/lipids - specifically for listeners that outlines key labs to discuss with your providers and questions to ask them to help you advocate for your own health and your family members' health. IN THIS EPISODE, YOU WILL LEARN: Why being physically fit does not always eliminate the risk of heart problems arising How ApoB and cholesterol contribute to heart disease over decades Why the early testing of risk factors is essential How chronic stress increases the risk of heart disease How high cortisol affects insulin sensitivity and glucose regulation How stress impacts endothelial and nitric oxide function The link between low Omega-3 levels and heart problems How insulin resistance degrades heart health How high homocysteine levels can impair endothelial function and contribute to cardiovascular problems Connect with Cynthia Thurlow Follow on⁠ X⁠,⁠ Instagram⁠ &⁠ LinkedIn⁠ Check out Cynthia’s⁠ website⁠ Submit your questions to [email protected] Join other like-minded women in a supportive, nurturing community ⁠(The Midlife Pause/Cynthia Thurlow⁠)⁠ ⁠ Cynthia’s⁠ Menopause Gut Book⁠ is on presale now! Cynthia’s⁠ Intermittent Fasting Transformation⁠ Book ⁠The Midlife Pause supplement line⁠ Connect with Dr. Thomas Dayspring On X (@DrLipid) On LinkedIn

Transcript

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0:00.0	Welcome to Everyday Wellness Podcast.
0:03.7	I'm your host, nurse practitioner, Cynthia Thurlow.
0:07.4	This podcast is designed to educate, empower, and inspire you to achieve your health and wellness goals.
0:13.9	My goal and intent is to provide you with the best content and conversations from leaders in the health and wellness industry each week and
0:21.5	impact over a million lives.
0:29.1	Today is a continuation of a previous Ask Me Anything with Dr. Tom Dayspring.
0:34.6	As I've mentioned before, I've done now eight podcasts with Dr. Dayspring, and he is an esteemed
0:41.3	expert on internal medicine and clinical lipidology.
0:44.7	He's arguably one of the most influential lipid experts, not only within the United States,
0:50.9	but worldwide.
0:51.6	And I'm very honored to have him back today to dive into topics related to listeners'
0:57.1	questions, including the impact of hormone replacement therapy on lipid changes, how the
1:02.3	route of administration, as well as the type of hormone replacement therapy, specifically
1:08.6	bioidenticals, are preferred for managing not only menopausal
1:14.0	symptoms, but also lipids, specific medications, including the PCSK9 inhibitors and new therapies,
1:21.0	the role of GLP1s and intermittent fasting. And very transparently, Dr. Dayspring indicated that he did not feel like he
1:29.9	was in a position to be able to speak about GLP1 therapies and or microdosing. And so for listeners,
1:37.1	because there were so many questions that came in, I will do a separate AMA just with me. And I will
1:42.0	address some of the specific concerns. We then went on to speak about
1:46.0	lipids and cardiovascular disease risk and why heart disease is actually a fairly slow process,
1:53.2	the impact of stress and other lifestyle measures, and recommended labs beyond the traditional lipids,
1:59.7	things beyond APOB and LPP-P-L-A.
	...

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