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Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

Ep. 518 Finally! The FDA Fix That Could Transform Hormone Therapy Safety & Confidence

Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

Cynthia Thurlow

Alternative Health, Nutrition, Science, Life Sciences, Health & Fitness

4.81K Ratings

🗓️ 14 November 2025

⏱️ 20 minutes

🧾️ Download transcript

Summary

It’s Nurse Practitioners Week, and today, we have a special episode to highlight a historic moment in time. On November 11, the FDA changed the labeling on hormone replacement therapy.  Join me for a short, focused episode where I read a recently published JAMA article detailing those changes, to keep you up to date on this significant development. IN THIS EPISODE, YOU WILL LEARN: How recent FDA updates are changing menopausal hormone therapy The history of estrogen’s role in heart and bone health How past research sparked fear around hormone therapy What the new labeling means for patients and prescribers How individualized treatment is reshaping dosage and timing decisions. Updated FDA labeling now distinguishes between systemic and topical therapies Key considerations for menopause-related urinary and genital health How these updates will potentially impact women’s long-term health Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to [email protected]

Transcript

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0:00.0

Welcome to Everyday Wellness Podcast.

0:03.7

I'm your host, nurse practitioner, Cynthia Thurlow.

0:07.4

This podcast is designed to educate, empower, and inspire you to achieve your health and wellness goals.

0:13.9

My goal and intent is to provide you with the best content and conversations from leaders in the health and wellness industry each week and

0:21.5

impact over a million lives.

0:28.9

This is updated labeling for menopausal hormone therapy.

0:33.1

Martin McCari is the primary physician listed on this.

0:37.5

And it says the role of estrogen replacement for perimenopausal and menopausal women

0:42.6

has been the subject of controversy.

0:44.4

In the mid-20th century, clinicians observed that women who underwent bilateral ophrectomy

0:50.3

before menopause, it means they had a total abdominal hysterectomy. Bilateral ophrectomy

0:57.1

means they had their oberies removed before menopause faced heightened cardiovascular disease

1:01.6

risk suggesting that estrogen may have cardioprotective effects. In 1942, the U.S. Food

1:08.1

and Drug Administration approved the first formulation for the treatment of menopausal symptoms.

1:12.6

Current evidence suggests that hormone therapy initiated within a decade of the onset of perimenopause has been associated with numerous long-term health benefits, including reduced vasemotor symptoms without significantly affecting askerotic cardiovascular disease, heart disease.

1:28.6

Among younger menopausal women age 50 to 59, remember that heart disease is the number one killer

1:35.5

of women, one and three.

1:37.4

Are you feeling like your energy isn't what it used to be?

1:40.7

Maybe your recovery from workouts is taking longer or you notice those subtle shifts and

1:45.4

stamina that come with midlife. The truth is one of the biggest factors behind this is declining

1:50.8

mitochondrial function are cells powerhouses that help create energy. That's where timeline

1:58.1

might appear comes in. Mitapeer is the first clinically tested supplement that directly targets and renews your

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