4.8 • 17.1K Ratings
🗓️ 19 February 2019
⏱️ 87 minutes
🧾️ Download transcript
This week's episode is nothing like any of our past episodes, and there will never be another quite like it. How can we be so sure, you ask? Because this week, we're covering prions, the terrifying, genetic material-less infection that is 100% fatal and caused by nothing more than a humble protein. And not just any protein, a protein you already have in your body. Are you sweating yet? Good. Then settle in and listen to the amazing biology of this terrifying twisted proteinacious particle, the fascinating and fraught history that led to its discovery, and the current research on just how scared you need to be of prions in your brain.
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0:00.0 | This is exactly right. |
0:04.3 | Typically, one day in middle age, the sufferer finds that he has begun to sweat. |
0:13.0 | A look in the mirror will show that his pupils have shrunk to pinpricks and he is holding |
0:17.1 | his head in an odd, stiff way. |
0:20.0 | Constipation is common, the women suddenly enter menopause and the men become impotent. |
0:25.2 | The sufferer begins to have trouble sleeping and tries compensating with a nap in the afternoon |
0:30.2 | but to no avail. |
0:32.0 | His blood pressure and pulse have become elevated and his body is an overdrive. |
0:37.6 | Over the ensuing months, he tries desperately to sleep, sometimes closing his eyes but never |
0:42.0 | succeeding and falling into more than a light stupor. |
0:45.5 | Their exhaustion is immense, beyond comprehension. |
0:49.6 | Once the sufferer can no longer sleep, a downward progression ensues as he loses his ability |
0:54.9 | to walk or balance. |
0:57.8 | This most tragic, the ability to think remains intact, sufferers know what is happening. |
1:03.0 | At first they can talk about it and even write down their thoughts. |
1:06.7 | After a few more months, some lose this level of functioning. |
1:10.7 | Once their bodies shut down, only the desperate look in their eyes shows that they know what |
1:15.1 | is going on. |
1:16.7 | But others can talk in reason until the end. |
1:19.9 | In the terminal phase, usually about 15 months after the disease has begun, they fall into |
1:25.2 | a state of exhaustion resembling a coma and die. |
1:55.2 | Oh, yeah. |
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