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A pathologist, R.S., age 30 years, had been working with Rift Valley Fever virus for several

weeks before the onset of his illness.

On the evening of December 22nd, 1932, he felt chilly while walking home and complained that his

eyes and the calves of his legs ached. During the night, his rest was disturbed by general malaise

and pains, especially around the knees and hips. On awakening, the second day of illness,

his temperature was 101 Fahrenheit. He attempted to continue his work, but had several chills

during the day and felt so miserable that he took to bed. He complained at this time of a vague

soreness over his abdomen, constant dull headache, and pain behind the eyes associated

with slight photophobia. There was no sore throat, rhinitis, nausea, or vomiting. He was admitted

to the hospital of the Rockefeller Institute 24 hours after the onset of symptoms. On admission,

the temperature was 102.6 Fahrenheit, pulse 140, respirations 24.

The patient was definitely prostrated by his illness, but rational and cooperative.

The throat culture was negative for hemolytic streptococci and influenza bacilli, and blood

cultures in infusion broth remained sterile. A tentative diagnosis

of Riff-Felly fever or influenza was made. In an attempt to confirm the tentative diagnosis

of Riff-Felly fever, six Cs of the patient's blood was injected into six mice. All of the mice

...