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Unresolved

Encephalitis Lethargica

Unresolved

Unresolved Productions

True Crime, Society & Culture, History

4.52.6K Ratings

🗓️ 11 November 2025

⏱️ 38 minutes

🧾️ Download transcript

Summary

"No fiction author would have had the temerity to invent a disorder of such incredible clinical diversity and puzzling behavior."

In the winter of 1916-1917, as World War I raged, physicians in Europe began noticing bizarre cases of brain illness. Thousands arrived at hospitals with high fevers, headaches, confusion, and a host of other factors - suspected at first to be meningitis or even poisoning - yet none of the explanations fit. What all of these patients shared was either an overwhelming drowsiness or psychotic agitation.

By late 1918, as the great influenza pandemic struck, this new "sleeping sickness" had spread across Europe and Beyond. Earlier that year, outbreaks were noted in England and the first American case was reported in September. By 1919, enough cases had surfaced worldwide that health officials realized they faced an epidemic of a baffling new illness...



Research & writing by Micheal Whelan and Amelia White

Hosting & production by Micheal Whelan

Learn more about this podcast at http://unresolved.me

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Transcript

Click on a timestamp to play from that location

0:00.0

This episode contains graphic content that may not be suitable for all ages.

0:08.0

Listener discretion is advised.

0:10.0

If you or someone you know is struggling or in crisis, help is available.

0:15.0

Call or text 988 or chat with someone at 988 lifeline.org. Those outside of the US, reach out to someone at your local crisis center or hotline.

0:25.6

Please do not suffer in silence.

0:32.6

1924. London. During the nightly rounds at a hospital ward, things felt unusually quiet.

0:44.4

In bed after bed lay patients locked in uncanny slumber.

0:48.5

One young woman, normally vivacious and 20 years of age, now barely stirred. Her eyes, when they opened at all,

0:56.0

were blank and unseeing. Middle-aged man sat propped against pillows, frozen in a statue-like

1:02.2

pose with one arm mid-gesture, as if turned a stone. Across the room, another patient suddenly

1:08.7

let out a delirious murmur, then just as quickly

1:11.9

lapsed back into silence.

1:14.0

The only real sound was the ticking clock and the faint breaths of the afflicted.

1:19.5

Doctors whispered of sleepy sickness, an illness that gripped its victims in unrelenting

1:24.3

lethargy or strange waking trances.

1:28.0

Families kept vigil by bedsides, watching their loved ones hover between life and becoming

1:33.0

living ghost.

1:34.7

It was a scene at once medical and otherworldly, an early glimpse into a medical mystery unfolding

1:41.5

across the world.

1:43.6

This is the story of encephalitis lethargica.

1:47.0

In the winter of 1916 going into 1917, as World War I raged, physicians in Europe began

2:08.0

noticing bizarre cases of brain illness.

...

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