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The Life Scientific

Elspeth Garman on crystallography

The Life Scientific

BBC

Technology, Personal Journals, Society & Culture, Science

4.61.4K Ratings

🗓️ 7 October 2014

⏱️ 28 minutes

🧾️ Download transcript

Summary

Jim al-Khalili talks to Professor Elspeth Garman about a technique that's led to 28 Nobel Prizes in the last century. X- ray crystallography, now celebrating its 100th anniversary, is used to study the internal structure of matter. It may sound rather arcane but it's the reason we now know the structure of hugely important molecules, like penicillin, insulin and DNA. But while other scientists scoop up prizes for cracking chemical structures, Elspeth works away behind the scenes, (more cameraman than Hollywood star), improving the methods and techniques used by everybody working in the field. If only it was as simple as putting a crystal in the machine and printing off the results. Growing a single crystal of an enzyme that gives TB its longevity took Elspeth's team no less than fifteen years. No pressure there then when harvesting that precious commodity.

Transcript

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0:03.8

podcast I work on. I'm Dan Clark and I commissioned factual podcasts at the BBC.

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0:36.1

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0:39.8

Thank you for downloading the Life Scientific from BBC Radio 4.

0:44.0

In case you missed it, this year is International Year of Crystallography.

0:49.0

We're celebrating a hundred years of X-ray Crystallography, a scientific technique that's used to study the

0:54.4

internal structure of matter. It may sound rather arcane, but in the last century

0:59.6

it's led to 28 Nobel Prizes. That's almost won every three years. X-rays are of course used to

1:06.5

provide useful images of our bones, but even more clever is the technique of X-ray diffraction, which allows us to penetrate matter and reveal

1:15.0

the internal shape and structure of all sorts of different molecules.

1:19.3

From salt at the turn of the last century to insulin and penicillin.

1:23.2

It is an incredibly powerful tool and it's important because by understanding the precise

1:28.2

shape and structure of molecules we can understand how they work. We can now make synthetic insulin, for example, or develop drugs that block the action of harmful molecules.

1:39.0

Oxford Universities, Professor El Smith-Garmon, is one of the world's leading authorities in the field.

1:44.8

While others have scooped up prizes for cracking structures of medically important molecules,

1:50.0

Elspeth has dedicated most of her working life to improving the methods and techniques used by everybody working in the field,

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