Elizabeth Fisher: Chromosomes in mice and men

Discovery

BBC

Science, Technology

4.3 • 1.2K Ratings

🗓️ 30 March 2020

⏱️ 28 minutes

🔗️ Recording | iTunes | RSS

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Summary

Elizabeth Fisher, Professor of Neurogenetics at University College London, spent 13 years getting her idea – finding a new way of studying genetic disorders – to work. She began her research career at a time, in the 1980s, when there was an explosion of interest and effort in finding out what genes did what, and which of them were responsible for giving rise to the symptoms of various neurodegenerative conditions. Elizabeth has been particularly interested in those in which there are chromosomal abnormalities, like Down syndrome and Turner syndrome, as distinct from specific genetic disorders. Her work has helped in the understanding of what’s different about the genetic make-up of people with these conditions, and what new therapies might be developed in the future. Lizzie Fisher talks to Jim al-Khalili about how she was inspired to study genetics while standing on the red carpet, how she kept going during the 13 years it took to introduce human chromosomes into mice and why she's starting the process all over again.

Transcript

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0:40.0	This is Discovery from the BBC. I'm Jimel Kulele and in today's program I'm in conversation with a leading scientist about their life and research. Welcome to the life scientific.
0:52.0	Where do scientists have their best ideas? Welcome to the Life Scientific.
0:52.8	Where do scientists have their best ideas?
0:55.7	In the laboratory, in the library, in the bath.
0:59.2	My guest today says the idea that set her on her life's work came to her and a group of her friends and
1:04.3	colleagues down the pub. Elizabeth Fisher then spent 13 years getting her idea, finding
1:11.0	a new way of studying genetic disorders, to work.
1:14.0	She began her research career at a time in the 1980s when there was an explosion of interest
1:19.1	and effort in finding out what genes did what, and of relevance here, which of them were responsible
1:25.2	for giving rise to the symptoms of various neurodegenerative conditions.
1:29.8	Elizabeth has been particularly interested in those in which there are chromosomal abnormalities
1:34.8	like Down syndrome and Turner syndrome as distinct from specific genetic disorders.
1:40.3	And her work has helped us understand what's different about the genetic makeup of people
	...

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