Hello and welcome to the zero to finals podcast. My name is Tom and in this episode I'm going to be going

through Erla's Danlos syndrome. And you can find written notes on this topic at zero tofinals.com

slash earla's Danlos syndrome or in theheumatology section of the second edition of the

Zero to Finals Medicine book. So let's get straight into it.

Erla's Danlos syndrome, or EDS, is a group of genetic conditions involving defects in

collagen, causing hypermobility in the joints and abnormalities in the connective tissue

of the skin, bones, blood vessels and organs.

Atomt it for you, Marfan syndrome is a key differential diagnosis for hypermobility.

Key features of Marfan syndrome are a high-arched palette, arachnodactyl

or long fingers, and an increased arm span to body height ratio. Let's start by going through the types.

Hypermobile Erlos-Danlos-Danlos syndrome is the most common and least severe type of Earless-Danlos syndrome,

although it still causes significant disability and psychosocial issues.

Features include joint hypermobility and soft and stretchy skin.

A single gene for hypermobile Erlus Danlos syndrome has not been identified.

It appears to be inherited in an autosomal dominant pattern.

Classical Erlos Danlos syndrome features remarkably stretchy skin that feels smooth and velvety.

There is severe joint hypermobility, joint pain and abnormal wound healing.

Lumps often develop over pressure points such as the elbows.

Patients are prone to hernias, prolapses, mitral regurgitation, and aortic root dilatation.

Inheritance of classical Erlostanloss syndrome is autosomal dominant.

Vascular Erlostanloss syndrome is the most severe and dangerous form of the condition,

where the blood vessels are particularly fragile and prone to rupture.

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