EFR 913: Why GLP-1 Medications Work (and When They Don't): The Hidden Hormone Story Behind Ozempic & Wegovy with Ashley Koff

Ever Forward Radio with Chase Chewning

Chase Chewning

Healthcoach, Education, Self-improvement, Mental Health, Wellness, Fitness, Humanoptimization, Resiliency, Holistic, Highperformance, Coaching, Biohack, Health, Military, Entrepreneurship, Mindset, Health & Fitness

5 • 927 Ratings

🗓️ 8 December 2025

⏱️ 99 minutes

🔗️ Recording | iTunes | RSS

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Summary

This episode is brought to you by Joi & Blokes, Troscriptions, and Caldera Lab.

In this episode of Ever Forward Radio, registered dietitian Ashley Koff, RD breaks down the truth behind GLP-1 medications like Ozempic and Wegovy, reframing them not as magic weight-loss shots but as hormone replacement therapies that reveal how dysfunctional most people's "weight-health hormones" have become. Ashley shares how digestion, nutrient status, genetics, and modern environmental pressures diminish the body's natural ability to regulate appetite, cravings, metabolism, and fat distribution — and why GLP-1 drugs can offer clarity but not a cure unless the underlying issues are addressed. She dives into muscle preservation, the limitations of BMI, the importance of fat-mass vs. scale weight, the root-cause approach to sustainable weight health, and what the future of GLP-1s means for generational wellness. This is a powerful conversation that blends science, personal insight, and actionable strategies to improve metabolic health — with or without medication.

Follow Ashley @ashleykoffapproved

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00:00 – GLP-1 hype: weight loss, risks, and whole-body benefits

02:00 – What GLP-1 drugs actually do in the body

02:20 – Understanding "weight-health hormones"

03:00 – Why society is functioning with suboptimal hormones

12:00 – Why total weight doesn't matter — muscle, fat, and bone do

14:00 – BMI is broken and misleading

15:00 – Weight regain, muscle loss, and metabolism

17:00 – Genetics, survival traits, and appetite regulation

23:00 – Root-cause approach: digestion, nutrient status, vagus nerve work

26:00 – How GLP-1s validate hormone dysfunction

28:00 – Side effects like nausea and constipation explained

30:00 – Why digestive repair is essential for long-term success

33:00 – How GLP-1s quiet obsessive thoughts, cravings, and food noise

36:00 – Supplements that support GLP-1 and weight-health hormone function

38:00 – Hop extract research and natural "GLP-1 activators"

42:00 – Limitations of natural alternatives vs. true hormone replacement

1:12:00 – Glucose spikes, CGMs, and metabolic flexibility

1:27:00 – The future of GLP-1s and redefining "obesity"

1:28:00 – Generational weight health and epigenetics

1:29:00 – Final thoughts and Ashley's Ever Forward message

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Get Ashley's book on Amazon

Transcript

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0:00.0	The following is an Operation Podcast production.
0:04.1	GLP1 drugs like OZembe and Wagovi are everywhere right now.
0:08.5	And for good reason.
0:09.6	In one major study, in fact, people lost and actually kept off up to 20% of their body weight over two years.
0:17.0	That's huge.
0:17.8	That's 40 pounds for someone who weighs 200.
0:22.9	Nearly 8 out of 10 participants saw real results. And researchers are finding benefits that go way beyond weight loss. We're talking
0:30.1	about improvements in liver health, even early signs that they may lower the risk of Alzheimer's,
0:35.2	but it's not all hype. There are also concerns about
0:39.0	muscle loss and other side effects, known and unknown, things we haven't seen yet. And let's be
0:45.1	real. These drugs can be expensive. So what's fact, what's fiction, and what should you know
0:52.0	before even considering them? Today, I'm joined by registered dietitian
0:56.8	Ashley Koff to break it all down. Hi, I'm dietitian Ashley Koff. I'm founder of your best shot
1:02.7	in the Better Nutrition program and welcome to Ever Forward Radio. And I've been a practice for a little 25, 27 years, and, you know, in Los Angeles.
1:19.4	So I've sort of ridden the trend of all of these different skinny shots.
1:22.6	You know, it kind of feels like I remember when it was Adderall.
1:24.7	And I remember, like, you know, kind of rolling through all these different.
1:27.2	When I first heard about JLP1, it was because it was Adderall and I remember like you know kind of rolling through all these different when I first heard about GLP1 it was because it was not when I went to school to become a
1:32.6	dietitian and I would offer that most physicians are also not learning about this when they go to
1:37.0	school to become a physician but it was when I saw my first bariatric patient so in about 2004
1:43.1	when I saw bariatric patients, I saw,
1:46.3	we were actually going in and figuring out, like, how is it that literally overnight your diabetes
	...

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