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Finding Genius Podcast

Effective New Migraine Medication Suitable for Patients with Vascular Issues: Kate Mullin Explains

Finding Genius Podcast

Richard Jacobs

Medicine, Health & Fitness

4.4 • 1K Ratings

🗓️ 15 May 2020

⏱️ 23 minutes

🧾️ Download transcript

Summary

Kathleen Mullin Bio:

Kathleen Mullin, M.D., is the Medical Director for Clinical Research at the New England Institute for Clinical Research and the Associate Medical Director at the New England Institute for Neurology and Headache (NEINH). Dr. Mullin is board-certified in neurology and headache medicine and after graduating from Tufts University and New York University School of Medicine, she completed her residency training at Columbia Presbyterian Hospital, followed by a fellowship in Headache Medicine at Montefiore Medical Center.

Prior to joining NEINH, Dr. Mullin was the Assistant Professor in the Department of Neurology at Montefiore.  She was also Director of Clinical Trials, overseeing a busy clinical trials program. She has been a principle and a sub-investigator on numerous studies, with her work being published in peer-reviewed journals and presented at national meetings.



Newer migraine medications are designed to address a different arm of the pain source than traditional triptan therapy, an approach not usable by patients with vascular issues.

Dr. Mullin explains

  • How this medication works by blocking CRPG receptors and why that makes a difference
  • What exactly defines a medication as being effective and how Nurtec™ fits the definition, and
  • How to let your doctor know about these newer medications.

Kathleen Mullin, MD, is the Medical Director of the New England Institute for Clinical Research (NEICR) in Stamford and specializes in headache medicine. A neurologist by training, she continued working in headache medicine after a fellowship following medical school and has never looked back. She is a clinician who also helps companies run migraine medication trails on her patient population and has found a very effective new medication that's now FDA approved: Nurtec™.

She explains how this works differently than the common triptan line of medicines, which work to decrease inflammation through vascular shrinking. However, any patient with a vascular condition of any sort is not able to take these medicines.

She explains how the migraine medication Nurtec™ binds with CGRP receptors; GCRP is a neuropeptide that we all have in our bodies. Migraine sufferers have an increased amount of them and blocking their ability to bind blocks their ability to cause pain.

Therefore, medications that work this way are called CGRP antagonists.  She discusses the success patients have had with this who haven't found relief with any other medication

She adds that headaches are wildly underdiagnosed and urges listeners to seek out medical help if they suffer from headaches. She says that if you ever had a headache that made you feel you had to cancel something, you probably had a migraine—so go to the doctor, she advises.

For more about Nurtec™, see https://www.nurtec.com/ .

Transcript

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0:00.0

Forget frequently asked questions.

0:02.0

Common sense, common knowledge, or Google.

0:05.0

How about advice from a real genius?

0:07.0

95% of people in any profession are good enough to be qualified and licensed.

0:11.0

5% go above and beyond. They become very good at what they do, but only 0.1% are real Jesus.

0:18.0

Richard Jacobs has made it his life's mission to find them for you. He hunts down and interviews geniuses in every field,

0:25.0

sleep science, cancer, stem cells, ketogenic diets, and more. Here come the geniuses.

0:30.3

This is the Finding Genius Podcast.

0:33.0

That is Richard Jacobs.

0:35.0

So this is Richard Jacobs with the Finding Genius Podcast.

0:41.0

I have Dr. Kathleen Mullen. She goes by Kate. She's a medical director at

0:46.4

Stanford for any ICR. We're going to talk about migraines and the rest of it's a big technical I'll let her explain about research

0:54.4

around migraines and medication. So Kate thanks for coming how you doing? I'm good

0:58.6

thanks for having me. Yeah so are you working on a specific medication for migraines or what's what's your work about?

1:06.0

So I am a clinical physician so I have been seeing I am a neurologist by training and then I did an additional what's called a fellowship year specifically for headache medicine and I've been seeing strictly headache patients since my first day of fellowship so for for over 10 years, that's all I do, and that's all I see.

1:26.0

In addition to my clinical practice, where I see and treat patients like a Dr. Wood,

1:31.0

we run research trials where pharmaceutical companies approach us because of our patient

1:36.6

population when they have a potential new drug coming down the pipeline, and we recruit patients from our practice to see if they would like to try

1:45.0

potentially new and different migraine medications. Okay and so what's the

1:50.0

latest and greatest in the migraine medication? It looks like there's a new one that's coming.

1:54.4

Yes, so actually the most recently FDA approved migraine medication and there actually has been

1:59.7

sort of a slew of them in the past year after decades of nothing but the most recent is called

...

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