Ebola Virus Disease - part 2
Hospital and Internal Medicine Podcast
Gil Porat, M.D., FACP, CPT
4.7 • 587 Ratings
🗓️ 30 October 2014
⏱️ 11 minutes
🧾️ Download transcript
Summary
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| 0:00.0 | The humor writer Andy Borowitz recently wrote, |
| 0:03.4 | There is a deep-seated fear among some Americans that an Ebola outbreak can make the country turn to science, |
| 0:11.0 | which rivaled an onion article titled, |
| 0:14.0 | Experts Say, Ebola Vaccine, at least 50 white people away. |
| 0:19.1 | So maybe starting off part two on this topic of Ebola with a focus on some |
| 0:26.4 | science will be a good place to start today. Let's talk about Ebola and the immune system. Do you |
| 0:33.4 | remember from immunology what dendritic cells are? Those are not to be confused with dendrites |
| 0:39.4 | found on nerve cells. Dendritic cells come out of our bone marrow and search for viruses and |
| 0:45.6 | bacteria, and they are antigen-presenting cells that help T-cells respond to foreign antigens. |
| 0:51.7 | So dendritic cells are found in lymph nodes. They also circulate in the blood, |
| 0:57.1 | and they are also present in some other areas of the body as well. These dendritic cells were first |
| 1:03.3 | described by Paul Langerhans in the late 19th century, but the central role of dendritic cells |
| 1:09.8 | in the adaptive immune response was described by a guy named Ralph Steinman in 1973, and he would receive the Nobel Prize in physiology and medicine in 2011 for that work on the immune system. |
| 1:23.7 | And by the way, the day the email arrived on his cell phone that he got the Nobel |
| 1:28.9 | Prize award would have been very exciting for him. The problem was he had just died of a four-year |
| 1:36.0 | battle with pancreatic cancer. But these dendritic cells are very important, and several studies have |
| 1:42.5 | been showing that Ebola virus attacks |
| 1:45.7 | these dendritic cells early. That's a bummer of a situation that hampers the immune response. |
| 1:53.0 | It appears that one of the great determining factors as to whether or not you survive |
| 1:58.5 | Ebola is whether your immune system eventually starts making |
| 2:02.0 | antibodies against the virus. Therefore, the early attack on dendritic cells is like a country's |
| 2:08.9 | radar and the entire computer system being wiped out before a full-scale invasion. Dendritic |
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