Eat THESE Anti-Aging Mushrooms to Live Longer (Paul Stamets) : 1327

The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey

Fat, Health & Fitness, Meditation, Biohacking, Lifestyle, Diet, Science, Self-improvement, Fasting, Nutrition, Hacking, Fitness, Brain, Wellness, Education

4.6 • 7.3K Ratings

🗓️ 12 September 2025

⏱️ 33 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Want to biohack your biology with nature’s most powerful anti-aging compounds? In this episode, you’ll discover how medicinal mushrooms fuel neurogenesis, protect mitochondria, supercharge immunity, and even help save the planet’s pollinators. From sharper focus and deeper REM sleep to protecting DNA from oxidative stress, fungi are the ultimate biohacking tools for performance, resilience, and longevity.

Watch episodes on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

(Re-run) Host Dave Asprey sits down with legendary mycologist and author Paul Stamets and mushroom entrepreneur Julian Mitchell. Together, they uncover the science of fungi as medicine — how mushrooms repair nerves, fight viruses, act as prebiotics for your microbiome, and provide the ultimate anti-aging biohacks. You’ll also hear how fungi hold the key to saving pollinators, regenerating soil, and extending human longevity.

You’ll Learn:

• Which anti-aging compounds in mushrooms protect your mitochondria and DNA

• How lion’s mane stimulates nerve growth factor and improves memory, focus, and REM sleep

• Why oyster mushrooms may help fight flu viruses and reduce chronic inflammation

• How mushroom tinctures unlock more bioactive compounds than powders or capsules

• The surprising role fungi play in saving bees and restoring environmental balance

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Keywords: anti-aging mushrooms, Paul Stamets fungi, lion’s mane memory, mushroom tincture benefits, ergothionine mitochondrial protection, oyster mushroom flu prevention, reishi immune system, cordyceps endurance, turkey tail microbiome, medicinal mushroom research, fungi save the bees, chaga antioxidants, mushroom longevity biohack, mycelium networks, functional mushrooms anti-inflammatory, mushroom brain health, neurogenesis fungi, adaptogenic mushrooms, mushroom cooking bioavailability

• Lifecykel Mushroom Products - use code ‘DAVE20’ for 20% off: https://www.lifecykel.com/?rfsn=4497217.61b030&utm_source=refersion&utm_medium=affiliate&am…

• Paul Stamets’ Website: https://hostdefense.com/

Thank you to our sponsors!

• ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask.

Resources:

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

• 0:00 — Trailer

• 0:47 — Intro

• 6:15 — Mushrooms vs. Algae

• 10:21 — Mushroom Safety & Microbiome

• 12:24 — Mushrooms as Medicine

• 14:43 — Psychedelics & Microdosing

• 16:26 — Kakadu Plum & Prebiotics

• 18:07 — Oyster Mushrooms & Cooking

• 21:35 — Mushrooms & Bees

• 25:59 — Lion’s Mane & Chaga

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcript

Click on a timestamp to play from that location

0:00.0	What if there was something you could add to your water to make you perform better, have more energy, and protect your cells from damage?
0:07.0	Hydrogen is the smallest molecule in the universe, and the only one that can get deep inside your cells, mitochondria, and even your DNA.
0:15.0	It fuels energy production, crushes oxidative stress, and supports sharper brain function.
0:20.0	Hydrogen's a gas so you can't take it as a pill,
0:23.4	so you either have to breathe it in or infuse it into your water. But your tap, bottled, or filtered
0:29.1	water doesn't have it. That's why I use the Echoflask. Echoflask is a hydrogen generator that
0:34.3	uses advanced electrolysis and a proprietary proton exchange membrane to
0:39.7	infuse your water with pure hydrogen. No chemicals, no pH change, just therapeutic science-backed
0:46.4	hydrogen. I've noticed more energy, faster recovery, less inflammation, and mental clarity that
0:52.5	lasts all day. Go to echo water.com slash Dave and use code Dave10 for 10% off your echo flask.
1:00.2	You'll feel the difference in days.
1:03.4	Where do you see the future 20 years from now in terms of percentage of human diet from
1:09.0	mushrooms versus algae versus some sort of cultured cellular product
1:13.4	thing versus real food from soil.
1:15.3	Mushroom-based food's going to play a huge role in the future of food.
1:18.4	As they grow quickly, require very little resources in terms of water, power, and land,
1:23.4	and the amazing nutritional profile that they have and, of course, being 100% natural.
1:47.0	Most people love mushrooms, but about 2 to 5% of the population, they don't like mushrooms. I realize now that that's actually a scientific observation. It may be their microbiome is incompatible with the mushrooms as a prebiotic. Talk to me about how to cook mushrooms. That's the best way to cook them so that I get all my bioives. You're listening to The Human Upgrade with Dave Asprey.
2:03.2	He's a speaker, author, mycologist, medical researcher, and entrepreneur, and considered an intellectual and industry leader in habitat, using mushrooms as medicine and producing fungi fungi and considers himself a mycological warrior after 40 years plus in the Pacific Northwest. And he's come to believe that
2:11.2	habitats have immune systems, just like we do in our guts, and that mushrooms are the cellular
2:16.4	bridge between people and the environment.
2:20.6	And he believes that our close relationship to fungi can be the basis for novel pairings in the
	...

Please login to see the full transcript.

Previous episode | Next episode

Disclaimer: The podcast and artwork embedded on this page are from Dave Asprey, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of Dave Asprey and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.