Duloxetine Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5 • 716 Ratings

🗓️ 6 January 2022

⏱️ 16 minutes

🔗️ Recording | iTunes | RSS

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Summary

On this episode, I discuss duloxetine pharmacology, adverse effects, and common drug interactions.

Duloxetine is an SNRI that is used for depression, anxiety, and various pain syndromes like neuropathy and fibromyalgia.

Duloxetine can inhibit CYP2D6 which can lead to higher concentrations of clozapine and propranolol and lower activity of tamoxifen.

CYP1A2 inhibitors like ciprofloxacin can raise concentrations of duloxetine leading to an increased potential for adverse effects.

Transcript

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0:00.0	Hey, all, welcome back to the real-life pharmacology podcast. I'm your host pharmacist, Eric Christensen.
0:06.3	Thank you so much for listening today. Before we get into the drug of the day, as always, go check out
0:11.6	real-life pharmacology.com. Snag your free 31-page PDF. It is a study guide of the top 200 drugs.
0:20.3	Definitely a no-brainer to go through, refresh yourself with maybe some things that you've long forgotten.
0:26.6	Or if you're just getting into pharmacy school, nursing school, med school, and really want a resource to kind of help you through your learnings throughout college.
0:39.1	Definitely go check that out.
0:40.5	RealLifepharmacology.com.
0:42.5	Free PDF going to take only your email there.
0:45.7	So with that said, let's get into the drug of the day today, and that is duloxatine.
0:51.7	So I have covered SNRIs previously, but I wanted to dig a little bit deeper on this
0:57.8	drug specifically. Brand name of this medication is Symbalta. I have seen the brand name
1:07.8	Drizalma before, and that is a sprinkle-type product of duoxetine.
1:15.4	But by and large, in clinical practice, you're going to see Simbalta used most often.
1:22.6	This is an S-NRI.
1:25.3	It is also technically classified as an antidepressant, anti-anxiety medication at times.
1:33.3	Mechanistically, an SNRI, we're going to inhibit serotonin and norepinephrine reuptake.
1:41.7	So essentially increase the activities of these two neurotransmitters in the brain.
1:49.5	And that's going to potentially help treat depression, help treat anxiety, help treat various pain syndromes.
1:59.7	And interestingly, off-label, stress incontinence can also be a potential use
2:10.0	for this medication. Now, in clinical practice, where do I see it use the most? It's going to be
2:16.7	depression and pain syndromes by far.
2:20.1	Sometimes anxiety on occasion.
	...

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