Dr. Peter Attia Appears to Change His View of LDL Cholesterol

High Intensity Health with Mike Mutzel, MS

Mike Mutzel

Fasting, Nutrition, Autophagy, Ketogenic, Keto, Health & Fitness, Ketodiet, Medicine

4.8 • 1.2K Ratings

🗓️ 22 March 2025

⏱️ 29 minutes

🔗️ Recording | iTunes | RSS

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Summary

Let's break down key insights from a recent two-hour and 20-minute conversation between Dr. Peter Attia and renowned lipidologist Tom Dayspring.

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Show Notes: https://bit.ly/4hrDc72

Time Stamps:

0:00 Intro
0:52 Cholesterol’s Role in Atherosclerosis
1:51 Triglycerides & Insulin Resistance: The Overlooked Risk Markers
3:28 Lipoprotein Exchange & Insulin Resistance
7:18 Triglycerides to HDL Ratio as a Risk Indicator
8:36 Metabolically Healthy Phenotype & LDL:
9:20 Sauna Therapy for Cardiovascular Health:
11:00 Cholesterol, Endothelial Health & Plaque Formation:
14:53 Case Study: A 24-Year-Old Athlete with High LDL
21:00 Lipoprotein(a) (LP(a)) and Its Role in Cardiovascular Risk:

Transcript

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0:00.0	In today's show, we're going to unpack some highlights from a recent podcast from Dr. Peter Artia and Tom Dayspring.
0:05.3	This is a really good two-hour and 20-minute-long episode that I would highly encourage you check out.
0:09.4	But if you don't have time to download and watch or listen to the whole thing, we're going to highlight some of the key or salient takeaways from that episode.
0:17.2	Because as you likely know, the leading cause of premature mortality in both men and women
0:21.7	is cardiovascular disease. So every single person should care about reducing their risk for
0:25.6	cardiovascular disease. But as you likely know, Dr. Atia is very focused on APOB and or LDL cholesterol
0:32.7	lowering and reduction. And we'll talk about why that thesis, his thesis, stands that you should have a pretty
0:40.4	low LDL. I think, you know, from the patients that he's worked with and my general impression from
0:45.2	his videos and podcasts is lowers the better from his perspective in his patient clinical practice.
0:51.6	But he admits to and talks a lot about how cholesterol is necessary,
0:56.9	but it's insufficient to fully explain atherosclerosis or increased risk for developing
1:02.3	placking that can lead to either a cardiovascular event or a cerebrovascular event like a stroke.
1:08.4	And that is that the endothelial tissue that can trap L.D.L. cholesterol
1:12.8	becomes damaged when people have high blood pressure, insulin resistance, increase blood
1:18.0	viscosity, they don't exercise. And so it's, you know, cholesterol is not necessarily the sole
1:23.9	reason driving cardiovascular disease. It's necessary, but it's insufficient. I think that's a
1:28.5	really good a pracea or take home from the first hour of this discussion. Now, what really surprised
1:35.0	me about an hour and 20 minutes into this conversation, Tom Dayspring really talked about how
1:39.8	triglycerides and insulin resistance are a huge problem. And he mentioned that if he just had two
1:45.3	biomarkers to measure. Now, remember, this gentleman, I believe he's a lipidologist. He's been studying
1:52.5	lipids for most of his career, as I understand. He talked a lot about triglysteroids. Now, as you
1:58.8	know, we have a video that I published well over a year ago.
	...

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