Dr. Nir Barzilai: Can This Drug Slow Aging? The Science Behind Metformin

The Dr. Hyman Show

Dr. Mark Hyman

Health & Fitness, Nutrition, Medicine

4.6 • 8.7K Ratings

🗓️ 7 February 2024

⏱️ 110 minutes

🔗️ Recording | iTunes | RSS

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Dr. Nir Barzilai is a geroscientist, Chaired Professor of Medicine and Genetics, and the founder and principal investigator of the Einstein Nathan Shock Center and the Glenn Center for Excellence in Biology of Aging. He also studies families of centenarians that have provided genetic and biological insights on the protection against aging—with several drugs developed based, in part, on these paradigm-changing studies. He is also leading the TAME (Targeting/Taming Aging with Metformin) trial to prove to the FDA that aging can be delayed and to allow for next-generation interventions.

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In this episode we discuss (audio version / Apple Subscriber version):

The hallmarks of aging (9:01 / 7:10)
What causes the hallmarks of aging? (15:40 / 13:49)
Dr. Barzilai’s research on centenarians (23:16 / 21:25)
Why living to 100+ years is good for the economy (24:54 / 23:03)
What enables someone to live to 100 years old? (29:30 / 25:20)
Taking growth hormone and Metformin have different effects based on your age (36:58 / 32:48)
The connection between HDL cholesterol and longevity (43:36 / 39:26)
Dr. Barzilai’s research on Metformin (56:23 / 52:13)
How Metformin works in the body and on muscle growth (1:04:51 / 1:00:41)
Dr. Barzilai’s personal longevity (1:42:05 / 1:37:55)

Learn more about the Longevity Genes Project and the TAME Trial.

Get a copy of Age Later: Health Span, Life Span, and the New Science of Longevity

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Transcript

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0:00.0	Coming up on this week's episode of the doctor's pharmacy.
0:03.4	Remember Paul Simon had the 50 ways to leave your lover?
0:07.1	There are 50 ways to be centenarians.
0:09.7	We're trying to discover all of them. Hey everyone, it's Dr Mark here.
0:17.0	Optimizing your health and wellness is a lifelong journey
0:20.0	and we all know how important things like proper nutrition and exercise are to live better.
0:23.7	But I want to talk with you about another foundational tool for optimizing wellness that often gets overlooked.
0:29.5	Infrared sonas. Infrared sonas are extremely effective at reducing the body stress response and
0:34.8	creating balance in the autonomic nervous system. They can improve circulation, help with weight
0:38.8	loss, balance blood sugar, improve detoxification, each of which improves your brain function.
0:43.6	When it comes infrared sonas, my number one brand is Sunlighten.
0:46.6	Whether you're craving relaxation or deep sleep or detoxification, sunlight infrared sonas will
0:51.9	help you achieve your health and wellness goals.
0:54.0	From weight loss to muscle recovery and skin rejuvenation, their patented infrared technology
0:59.0	will restore your body and your mind.
1:01.0	Right now you can save up to $600 on your purchase. Simply visit
1:05.0	Sunlighten.com forth slash Mark dash Hymen and mention my name Dr. Hymen to
1:09.7	save. Sleep is foundational for health. It's really that simple. That means getting good quality sleep is a non-negotiable for me.
1:16.5	The problem is I have a terrible time getting comfortable in bed.
1:19.5	Regardless of the time of year, I simply get too hot to fall asleep. Thankfully I found an incredible
1:24.2	solution and I want to share it with you today. Cozy Earth Sheets. Let me tell you, they're
1:28.1	simply amazing. They feel like heaven to the touch and their premium fabric regulates your body temperature no matter the season
	...

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