Dr Jack Mosley
The Mid•Point with Gabby Logan
The Midpoint
4.3 • 1.6K Ratings
🗓️ 31 March 2026
⏱️ 35 minutes
🧾️ Download transcript
Summary
This week on The Midpoint, we’re joined by GP and media medic Dr Jack Mosley for a timely and much-needed conversation about GLP-1 medications — and what they really mean for our health in midlife.
Dr Mosley breaks down the science behind drugs like Ozempic and Wegovy, explaining how they work in the body, why they’ve become so popular, and what role they can (and should) play in weight management. With so much hype — and misinformation — surrounding these medications, he offers a clear, balanced view on who they’re for, the potential benefits, and the risks that are often overlooked.
We also explore the bigger picture: why midlife weight gain happens, how hormones, lifestyle and metabolism all intersect, and whether these medications are a long-term solution or simply part of a wider toolkit.
It’s an honest conversation about expectations, quick fixes, and the reality of sustainable health — without shame or judgment.
If you’ve been curious about GLP-1s, confused by the headlines, or wondering whether they might be right for you, this episode will help you make sense of it all.
Jack is working with The Fast 800 intermittent fasting plan. For a 7 day free trial of The Fast 800 online programme and for more info, please visit www.thefast800.com
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Transcript
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| 0:00.0 | Hello and welcome back to the midpoint. Today I'm very excited and delighted to have Dr Jack |
| 0:09.8 | Mosley in the studio. Jack has been a GP for seven years, but it looks like his area of interest |
| 0:15.5 | and expertise is going to continue to build on the brilliant work done by his late father, Dr Michael Mosley, |
| 0:21.9 | who many of us know as someone who's affable and easygoing broadcasting style |
| 0:25.9 | could also be termed as practicing what he preached. |
| 0:29.1 | Of course, his 5-2 diet where you fast for two days a week on just 800 calories, |
| 0:33.8 | and eat normally for the other five days was a huge hit. |
| 0:37.1 | Many people attributed enormous |
| 0:39.0 | weight loss to it and their long-term management also and still follow his plan today. His son Jack |
| 0:45.7 | has become an expert on GLP-1s and their long-term effects on our health. But he's picking up on |
| 0:51.8 | his late father's work with his latest project, The Fast 800. |
| 0:55.1 | So we're going to discuss that, all things fasting, and what he's learned about GLP ones. |
| 1:03.1 | Dr Jack Mosley, welcome to the midpoint. Yeah, thank you so much for having me, Gabby. I'm really |
| 1:07.8 | looking forward to this today. Well, I've, in your introduction, said that you seem to be developing, after seven or eight years as a GP, you seem to be |
| 1:14.9 | developing a real interest in some of the areas that we are kind of known your family for, |
| 1:20.9 | really, and your dad in terms of fasting. And now, GLP-1s have become such a huge topic |
| 1:27.4 | that you have found yourself getting very interested in them and their effects on people, not just while they're taking them, but afterwards as well. |
| 1:34.6 | So can we just go back and kind of work out, is this interest you think familiar? |
| 1:38.5 | It comes from your, you know, your background at home, or is this something that you as an academic as a doctor have found interesting? |
| 1:45.8 | Well, like you say, I've been working as a doctor for around eight years now, but I do have |
| 1:50.8 | a long background with my interest in this area. This lifestyle medicine, it was really in its |
| 1:58.0 | infancy when my dad really started developing a passion for this area, and especially it was really in its infancy when my dad really started developing a passion for this area. |
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