Dr. David Sinclair: The Biology of Slowing & Reversing Aging

Huberman Lab

Scicomm Media

Science, Health & Fitness, Life Sciences

4.8 • 26.2K Ratings

🗓️ 27 December 2021

⏱️ 131 minutes

🔗️ Recording | iTunes | RSS

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Summary

In this episode, I am joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don't Have To, and the host of the Lifespan Podcast, which launches January 5, 2022. In this interview, we discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. We discuss fasting and supplementation with resveratrol, NAD, metformin, and NMN. We also discuss the use of caffeine, exercise, cold exposure, and why excessive iron load is bad for us. We discuss food choices for offsetting aging and promoting autophagy (clearance of dead cells). And we discuss the key blood markers everyone should monitor to determine your biological versus chronological age. We also discuss the future of longevity research and technology. This episode includes lots of basic science and specific, actionable protocols, right down to the details of what to do and when. By the end, you will have in-depth knowledge of the biology of aging and how to offset it. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman InsideTracker: https://insidetracker.com/huberman Thesis: https://takethesis.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Dr. David Sinclair, Harvard Medical School (00:03:30) Sponsors (00:07:45) “Aging as a Disease” vs. Longevity & Anti-Aging (00:10:23) What Causes Aging? The Epigenome (00:15:53) Cosmetic Aging (00:17:15) Development Never Stops, Horvath Clock (00:20:12) Puberty Rate as a Determinant of Aging Rate (00:23:00) Fasting, Hunger & Food Choices (00:32:44) Fasting Schedules, Long Fasts, (Macro)Autophagy (00:34:50) Caffeine, Electrolytes (00:35:56) Blood Glucose & the Sirtuins; mTOR (00:37:55) Amino Acids: Leucine, “Pulsing” (00:44:35) Metformin, Berberine (00:50:29) Resveratrol, Wine (00:53:20) What Breaks a Fast? (00:56:45) Resveratrol, NAD, NMN, NR; Dosage, Timing (01:09:10) Are Artificial Sweeteners Bad for Us? (01:12:04) Iron Load & Aging (01:15:05) Blood Work Analysis (01:19:37) C-Reactive Protein, Cholesterol: Serum & Dietary (01:26:02) Amino Acids, Plants, Antioxidants (01:33:45) Behaviors That Extend Lifespan, Testosterone, Estrogen (01:40:35) Neuroplasticity & Neural Repair (01:46:19) Ice Baths, Cold Showers, “Metabolic Winter” (01:48:07) Obesity & How It Accelerates Aging, GnRH (01:52:10) Methylation, Methylene Blue, Cigarettes (01:56:17) X-Rays (01:59:00) Public Science Education, Personal Health (02:05:40) The Sinclair Test You Can Take: www.doctorsinclair.com (02:08:13) Zero-Cost Support & Resources, Sponsors, Supplements, Instagram Title Card Photo Credit: Mike Blabac Disclaimer

Transcript

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0:00.0	Welcome to the Huberman Lab podcast where we discuss science and science-based tools for everyday life.
0:09.0	I'm Andrew Huberman and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.
0:14.6	Today, my guest is Dr. David Sinclair, professor of genetics at Harvard Medical School and
0:20.2	co-director of the Paul F. Glenn Center for the Biology of Aging.
0:23.9	Dr. Sinclair's work is focused on why we age and how to slow or reverse the effects of aging by focusing on the
0:31.5	cellular and molecular pathways that exist in all cells of the body and that progress those cells over time from young
0:38.7	cells to old cells. By elucidating the biology of cellular maturation and aging,
0:45.1	Dr. Sinclair's group has figured out intervention points by which any of us, indeed all of us, can slow or reverse the
0:52.1	effects of aging. What is unique about his work is that it focuses on behavioral interventions, nutritional interventions, as well as
0:59.5	supplementation and prescription drug interventions that can help us all age more slowly and reverse the effects of aging in all tissues of the body.
1:09.1	Dr. Sinclair holds a unique and revolutionary view of the aging process, which is that aging is not the normal and natural
1:15.9	consequence that we all will suffer, but rather that aging is a disease that can be slowed or halted.
1:22.7	Dr. Sinclair continually publishes original research articles in the most prestigious and competitive scientific journals.
1:29.9	In addition to that, he's published a popular book that was a New York Times bestseller.
1:34.5	The title of that book is Life Span, Why We Age and Why We Don't Have To.
1:38.7	He is also very active in public facing efforts to educate people on the biology of aging and slowing the aging process.
1:45.3	Dr. Sinclair and I share a mutual interest and excitement in public education about science.
1:51.2	And so I'm thrilled to share with you that we've partnered and Dr. David Sinclair is going to be launching the Life Span podcast,
1:57.8	which is all about the biology of aging and tools to intervene in the aging process.
2:02.3	That podcast will launch Wednesday, January 5th.
2:05.9	You can find it at the link in the show notes to this episode today, as well.
2:10.7	You can subscribe to that podcast on YouTube, Apple, or Spotify or anywhere that you get your podcasts.
	...

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