meta_pixel
Tapesearch Logo
Log in
Nutrition Diva

Does Ozempic slow aging? Separating facts from hype

Nutrition Diva

Macmillan Holdings, LLC

Nutrition, Arts, Education, Health & Fitness, Food

4.41.8K Ratings

🗓️ 17 September 2025

⏱️ 12 minutes

🧾️ Download transcript

Summary

Could Ozempic slow—or even reverse—aging? We take a closer look at the science behind the buzzy headlines.

References:

Semaglutide Slows Epigenetic Aging in People with HIV-associated lipohypertrophy: Evidence from a Randomized Controlled Trial | medRxiv  [pre-print]

Once-weekly semaglutide in people with HIV-associated lipohypertrophy: a randomised, double-blind, placebo-controlled phase 2b single-centre clinical trial - PubMed

Find a full transcript here.

New to Nutrition Diva? Check out our special Spotify playlist for a collection of the best episodes curated by our team and Monica herself! 

We've also curated some great playlists on specific episode topics including Staying Strong as We Age, Diabetes, Weight Loss That Lasts and Gut Health! Also, find a playlist of our bone health series, Stronger Bones at Every Age

Have a nutrition question? Send an email to nutrition@quickanddirtytips.com.

Follow Nutrition Diva on Facebook and subscribe to the newsletter for more diet and nutrition tips. 

Find out about Monica's keynotes and other programs at WellnessWorksHere.com

Nutrition Diva is a part of the Quick and Dirty Tips podcast network.  


Hosted on Acast. See acast.com/privacy for more information.

Transcript

Click on a timestamp to play from that location

0:00.0

Could the weight loss drug that everyone is talking about also be the fountain of youth?

0:05.7

A new study just found that people taking semaglitead rewound the biological clock by an average of three years.

0:14.0

But before we start adding longevity to the drug's resume, I think we need to talk about what those numbers actually mean and who they

0:23.1

apply to.

0:28.3

Welcome to the Nutrition Diva podcast, where we take a closer look at nutrition news, research,

0:36.1

and trends, and answer your food and nutrition questions.

0:40.0

I'm your host, Monica Reinagle, and today I want to address some of the buzzy headlines that you

0:45.9

may have been seeing about the prescription drug semaglite. It's better known by brand names

0:51.4

like Ozympic and Weigovie, and its supposing anti-aging effects.

0:58.2

The study that sparked these headlines was a 32-week, double-blind, placebo-controlled, randomized trial.

1:06.2

So that is the gold standard for testing whether a treatment has real effects. But here's an important

1:13.3

detail right up front. The study participants were not representative of the general population

1:20.4

or of the vast majority of people who actually use these medications. So this study involved adults who are living with HIV.

1:30.3

And the trial was originally designed to see how somaglite might affect lipohypertrophy.

1:36.4

This is a condition that sometimes affects HIV patients, and it causes an abnormal accumulation of fat

1:43.6

in certain areas of the body. And somagletide was

1:47.9

found to be quite effective in managing this particular condition. But after the trial was over,

1:55.6

researchers then used some of the blood samples that they collected during the trial to do what's

2:00.2

called a post hoc analysis, where they go back and take another look at the data or the samples

2:07.2

that they've already collected to see if they can find any new or interesting patterns.

2:13.0

So that might mean separating out subgroups of participants, say only the women or maybe only people

2:21.3

over 50, and then re-analyzing the data for them separately to see if the results look any

...

Please login to see the full transcript.

Disclaimer: The podcast and artwork embedded on this page are from Macmillan Holdings, LLC, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of Macmillan Holdings, LLC and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.

Copyright © Tapesearch 2026.