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NutritionFacts.org Video Podcast

Do NAD+ Levels Decline with Age?

NutritionFacts.org Video Podcast

[email protected]

Health & Fitness, Nutrition, Alternative Health

4.8877 Ratings

🗓️ 19 March 2025

⏱️ 7 minutes

🧾️ Download transcript

Summary

What is NAD+ and what role does it play in the aging process?

Transcript

Click on a timestamp to play from that location

0:00.0

NAD Plus is an essential co-factor for hundreds of enzymes, including the purported anti-eaging

0:05.8

activities of CERTuins. In this 10-part video series, I will go through the alphabet soup

0:12.7

of NAD boosting supplements on the market, N-R-N-M-N-N-N-H, N-A, N-A-N-A-N-A-N-H and Triptophan.

0:22.1

I will then cover the pros and cons of each and discuss three ways to naturally boost NAD levels without supplements.

0:35.6

Our understanding of nicotinamide adenine dinuclidid, NAD+,

0:43.3

arose from humble beginnings as a factor noted to enhance yeast fermentation in a 1906 paper, unassumingly

0:51.0

entitled, the alcoholic ferment of yeast juice.

0:54.7

Little did they know that waves of NAD-related discoveries would go on to yield a total of four

1:00.1

Nobel Prizes. NAD Plus is now known as an essential molecule for all living organisms

1:06.1

required for the function of about 500 enzymes, including, notably, the extraction of metabolic energy

1:12.2

from food.

1:13.8

The 21st century has produced yet another scientific renaissance for NAD, with the realization

1:19.2

that it was critical for the activity of Sertuins, the Guardians of Mammalian Health

1:23.8

Span I detail in my book How Not to Age.

1:31.4

NAD is one of the most abundant molecules in our body.

1:36.5

Once considered relatively stable, it's now known to be in constant state of synthesis,

1:37.9

recycling, and breakdown.

1:43.7

The entire pool of NAD and some of our tissues is turned over several times a day. To maintain cellular vitality

1:46.2

in the face of this turnover, an adequate supply of NAD precursors and sufficiently high enzyme

1:52.2

activity synthesizing NAD are critical. The importance of NAD is exemplified by the devastating

1:59.2

consequences of a deficiency of NAD precursors like NIA-B3, a deficiency of NAD precursors like

2:02.4

niacin, vitamin B3, the deficiency syndrome called Pallegra, is characterized by the 4Ds,

...

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