Do NAD+ Levels Decline with Age?
NutritionFacts.org Video Podcast
Michael Greger, M.D. FACLM
4.8 • 952 Ratings
🗓️ 19 March 2025
⏱️ 7 minutes
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| 0:00.0 | NAD Plus is an essential co-factor for hundreds of enzymes, including the purported anti-eaging |
| 0:05.8 | activities of CERTuins. In this 10-part video series, I will go through the alphabet soup |
| 0:12.7 | of NAD boosting supplements on the market, N-R-N-M-N-N-N-H, N-A, N-A-N-A-N-A-N-H and Triptophan. |
| 0:22.1 | I will then cover the pros and cons of each and discuss three ways to naturally boost NAD levels without supplements. |
| 0:35.6 | Our understanding of nicotinamide adenine dinuclidid, NAD+, |
| 0:43.3 | arose from humble beginnings as a factor noted to enhance yeast fermentation in a 1906 paper, unassumingly |
| 0:51.0 | entitled, the alcoholic ferment of yeast juice. |
| 0:54.7 | Little did they know that waves of NAD-related discoveries would go on to yield a total of four |
| 1:00.1 | Nobel Prizes. NAD Plus is now known as an essential molecule for all living organisms |
| 1:06.1 | required for the function of about 500 enzymes, including, notably, the extraction of metabolic energy |
| 1:12.2 | from food. |
| 1:13.8 | The 21st century has produced yet another scientific renaissance for NAD, with the realization |
| 1:19.2 | that it was critical for the activity of Sertuins, the Guardians of Mammalian Health |
| 1:23.8 | Span I detail in my book How Not to Age. |
| 1:31.4 | NAD is one of the most abundant molecules in our body. |
| 1:36.5 | Once considered relatively stable, it's now known to be in constant state of synthesis, |
| 1:37.9 | recycling, and breakdown. |
| 1:43.7 | The entire pool of NAD and some of our tissues is turned over several times a day. To maintain cellular vitality |
| 1:46.2 | in the face of this turnover, an adequate supply of NAD precursors and sufficiently high enzyme |
| 1:52.2 | activity synthesizing NAD are critical. The importance of NAD is exemplified by the devastating |
| 1:59.2 | consequences of a deficiency of NAD precursors like NIA-B3, a deficiency of NAD precursors like |
| 2:02.4 | niacin, vitamin B3, the deficiency syndrome called Pallegra, is characterized by the 4Ds, |
... |
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