Divine Intervention Episode 507: The Clutch Sickle Cell Disease Podcast (for Step 1-3) Part 1

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Divine-Favour Anene

Medicine, Education, Science & Medicine, Higher Education

4.9 • 929 Ratings

🗓️ 30 January 2024

⏱️ 30 minutes

🔗️ Recording | iTunes | RSS

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Summary

Sickle cell disease is easily a multisystems processes and disorders topic on the USMLEs. It can be tested in a myriad of ways and our friends at the NBMEs have a unique way of extending this concept to so many other disciplines. The goal of this podcast is to help you understand sickle cell disease … Continue reading Divine Intervention Episode 507: The Clutch Sickle Cell Disease Podcast (for Step 1-3) Part 1

Transcript

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0:00.0	Welcome. This is episode 507 of the Divine Intervention Podcasts.
0:05.0	To this podcast, I'm going to be addressing sickle cell disease.
0:08.0	I'm going to call this the super high-yield sickle cell disease podcast.
0:12.0	This podcast is extremely high
0:14.1	yield and I know it's going to be about sickle cell disease but there are so many
0:19.5	integrations I'm going to make with so many disciplines. It's worth you a while even if you don't care to learn
0:25.2	about sequel cell disease or you feel like you know every single thing about sequel cell disease.
0:30.5	And again the way I'm going to introduce this is I'm going to give some background and then I'm going to start releasing some vignettes as we go along.
0:36.5	And honestly as I release these vignettes, right? You'll just see me say what if they ask you this? What if they ask you this?
0:41.2	It will kind of be very informal, but again, if you really pay attention here, you can get a ton from this.
0:46.7	And I'll really try to see if I can feed this into one podcast, but if I cannot, I'm just gonna make it in,
0:50.7	and make a part two, but honestly, there's a very, very, very high your podcast.
0:55.3	Okay, please just make sure you know the stuff. Okay, so single cell disease, we know the classic demographic that gets this, right?
1:04.2	It's almost always going to be in Africans on the US-M-L- exams.
1:07.2	It's going to be something you're going to see in Africans, right?
1:10.1	But just be careful, though, you may also see this in people that are Hispanic, people that are of Mediterranean ancestry, so people from Italy, from Libya, stuff like that, people that are Asian, right, and Indians, believe it or not, Asians and Indians can also have sickle cell disease.
1:25.0	Asians and Indians can also have sickle cell disease.
1:28.0	Right?
1:29.0	So what causes a sickle cell?
1:30.0	Well, it's pretty much a single single base change, right? Basically in the beta globin
1:35.7	gene you substitute a glutamic acid for veiling. So normally glutamic acid is supposed to be at that position six.
1:45.0	But then you're like, okay, well, because of some genetic mutation, the glutamic acid gets
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