Okay, welcome. My name is Devine. This is episode 423 of the Devine

Intervention Podcast. In today's podcast, I'm going to be continuing the rapid

review series for the USMI Step 2, second step 3 exams. This is going to be

series 86. All right. So what if they give you a question about a child that has, you tell you is a five-year-old boy, he has intellectual disability, has autistic features, has a long face,

has a large jaw, has big, many things are large here, right?

So long face, big jaw, big ears, big testicles, right?

Sometimes these are saying big testicles.

They'll use the term macro or kidism.

What should you be thinking about?

Well, I would really hope you're saying, oh, divine, this sounds an awful lot like fragile X syndrome.

Remember fragile X syndrome is one of the tranichotide repeats disorders and in this

tranquil thiothi repeat disorder, right?

First things first is to know the mode of inheritance.

Remember, it's X-linked dominant inheritance.

Really, there are two X-linked dominant disorders

that are friends at the MBMEs really want you to know.

One is Fragile X Syndrome.

The other one is Alport Syndrome.

Alport Syndrome is another pretty high-yield X-Lincdominant disorder

that you need to know for your exams. So the thing then that will be helpful here is asking ourselves, okay, what's the tranquil growth and repeat that's a sociality of fragile X syndrome. Well, it's the CGG

trying to do with that repeat.

I remember the gene that is messed up is the FMR 1 gene, right, the FMR 1 gene,

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