Welcome to episode 552 of the Divine Intervention Podcasts.

Into this podcast, we're going to finish up our discussion on the Iron Story and the USMLEs.

This is going to be part two.

So we're just going to jump right into it.

So if you remember, I would encourage you if you missed it, listen to episode 550.

Again, it may seem like some benign podcast. It may seem like, oh, I know everything about iron. Until you then notice that I proceed to make like lots of integrations in that podcast. I think you're going to find it to be extremely helpful. So just go back, listen to that. If you have not listened to it, we're going to pretty much pick up where we're left off. So let's start addressing some diseases. And honestly, my goal with today's podcast is to address a few diseases. But there is a lot of kind of weird integrations I want to make that I think are going to be very useful. And like, you may actually hear me talking about like a bunch of things you may think have no relationship with iron. but they actually pretty high yield to know for the exams. I'm going to really focus today on understanding pathophers, so that this stuff kind of clicks in your brain. So I think since we have that foundation in iron metabolism, now let's talk about some diseases. And the first one I'm going to talk about is hereditary hemocratosis. Hereditary hemocromatosis.

As many of you know, hereditary hemokromatosis, just to get the genetic stuff out of the way, it's from a HFE mutation.

And there are many different mutations that can cause this.

So HF is the gene.

A very common mutation that can cause this is the C2H2Y mutation.

That's actually the one that is the most common.

But another one that you may notice that can cause this is the H63D mutation, the H63D mutation.

And obviously, this gene mutation is on chromosome 6.

Okay, chromosome 6 is the gene.

Again, my goal with this podcast is to pretty much cover every base from step one to step

three.

And I think it's important to understand that this mutation that causes heritory hemokromatosis,

many times it's going to be a mis-s mutation, right?

So you pretty much have a switch in the amino acid structure and you switch an amino acid and you make a

different protein so remember it's not like a frame shift mutation because a frame shift mutation

remember is really bad you pretty much have an insertion or deletion that's not in a multiple of three

an indel that's not in a multiple of three you get in trouble um you pretty

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