Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, Eric Christensen.

Thank you so much for listening and sharing this podcast with friends and other healthcare professionals.

It's certainly greatly appreciated. If you enjoy the episode today, definitely do us a solid and leave us a rating and review on iTunes or wherever you're listening.

So with that, let's get into the drug I want to talk about today, and that's DeCycline.

The brand name of this medication is Bental.

And in clinical practice, pretty much the only thing I've ever seen this medication used for

is GI pain, GI spasms most often associated with irritable bowel syndrome.

Okay.

So there may be some off-label wacky use that somebody uses it for once in a while,

but by and large, the overwhelming majority of times you see this medication, it's going to be for

IBS and GI cramping and spasms and pain. It is an anticholinergic agent.

So we've talked about anticholinergics in previous episodes,

tricyclic antidepressants, I believe diphenhydramine I've covered.

So all those anticholinergic effects are going to come into play with diclinamine.

So just a reminder, you know, we're blocking the action of acetylcholine in the body.

And acetycholine is important in stimulating gut motility and also plays a role in memory.

And depending upon the subtype of receptors, muscarinic receptors that it binds to, there's all

sorts of different actions that I can have on various types of smooth muscle. So with

diclinamine specifically, it has been shown that it's mostly M1 selective, so

muscarinic type 1 selective. However, as we escalate doses, we have to realize that, you know, we sometimes

lose that selectivity. So at least in one article I saw, they talked about M1 being specific,

more so for the GI tract and salivary glands as well as the central nervous system.

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