Denis Noble: Why Genes Are Not the Blueprint for Life

Theories of Everything with Curt Jaimungal

Curt Jaimungal

Physics, Philosophy, Society & Culture, Science

4.6 • 606 Ratings

🗓️ 6 August 2024

⏱️ 40 minutes

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Summary

Denis Noble argues that genes are not a blueprint for life, challenging gene‑centric and neo‑Darwinian views while highlighting the role of systems biology in understanding living organisms. He discusses the scientific, medical, and philosophical implications of moving beyond a genome‑first perspective.- 00:00 - Intro- 02:05 - Overview of Lecture- 04:30 - What is the Genome?- 07:22 - Is the Genome the Book of Life?- 12:16 - 20th Century Gene-Centric Biology is Wrong- 18:03 - Neo-Darwinism is Incorrect- 19:42 - Implications for Medical Science- 27:17 - Next Steps for Biology- 33:10 - A Challenge to the World's ScientistsSPONSORS:- Patreon: https://patreon.com/curtjaimungal (early access to ad-free audio episodes!)- Crypto: https://tinyurl.com/cryptoTOE- PayPal: https://tinyurl.com/paypalTOE- TOE Merch: https://tinyurl.com/TOEmerchRESOURCES:- The Music of Life (Book) - https://amzn.to/4drSFSP- The Selfish Gene (Book): https://amzn.to/3zYLyTx- Understanding Living Systems (book): https://www.amazon.com/Understanding-Living-Systems-Life/dp/1009277367- Denis’ article: https://www.nature.com/articles/d41586-024-00327-x- The Third Way of Evolution (website): https://www.thethirdwayofevolution.com/ Theories of Everything with Curt Jaimungal features long-form, technically detailed interviews with leading researchers in physics, mathematics, consciousness, and philosophy, exploring topics at the level of active research. For academics, graduate students, and anyone seeking depth beyond popular science. SPONSOR: I personally subscribe to The Economist. TOE listeners get 35% off the annual subscription. No other podcast has this! https://economist.com/TOE FOLLOW: Substack | Spotify | YouTube | Twitter Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0	The central dogma of biology has ruled for decades, but what if it's fundamentally flawed?
0:07.0	Dennis Noble is a maverick biologist, a fellow of the Royal Society, and a professor at the University of Oxford,
0:15.0	who spent his career challenging the fundamental assumptions of modern genetics.
0:20.0	From pioneering computer models in biology in the 1960s to his current crusade against gene-centric biology,
0:28.3	Noble has never shied away from overturning scientific orthodoxy.
0:33.3	I'm Kurtzai Mungal, and in this lecture for my series on rethinking the foundations,
0:38.7	Noble makes the case that our understanding of life and evolution is due for a radical
0:44.9	overhaul, one that could revolutionize medicine and reshape our view of what it means
0:51.1	to be human.
0:56.7	Professor Dennis Noble, you're one of the pioneers of systems biology at Oxford University,
1:03.1	and also along with your collaborator Shapiro, you've spawned a concept called the Third Way of Evolution,
1:09.8	which we'll discuss in the subsequent Q&A.
1:13.4	For those of you who are watching, this is a presentation by Professor Dennis Noble for the
1:18.4	series here called Rethinking the Foundations of Biology, What Lies Beyond Darwin?
1:25.5	Dennis Noble will be giving the inaugural talk, and I'm almost uniformly
1:30.0	going to shut my mouth for the next 30 minutes, and in the second video, which is linked
1:35.1	in the description, we'll delve into the material from this one in the format of a podcast.
1:41.1	Take it away, Professor.
1:42.0	Well, thank you very much, Kurt. It's a pleasure to come
1:45.4	on to your series and rethinking the foundations of biology. I love that title because it's
1:54.5	precisely what is implied by the title I've used for this,
2:02.1	genes are not the blueprint for life.
	...

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