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Solvable

Decoding Psychedelics with Dr. Grace Blest-Hopley from Decoding Women's Health

Solvable

Pushkin Industries

Society & Culture, News

4.4602 Ratings

🗓️ 27 January 2026

⏱️ 48 minutes

🧾️ Download transcript

Summary

What if psychedelics could transform the way we treat trauma, chronic pain, and insomnia? This week, neuroscientist and psychedelic researcher Grace Blest-Hopley joins the show to break down the research on psychedelics and female biology. She discusses how psychedelics work in the brain, and the ways that psychedelic-assisted therapies might be beneficial for women in midlife.

Links to resources mentioned in this episode:

Hystelica’s resources on psychedelic retreats

The Heroic Hearts Project

Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics

Exploring the Therapeutic Effects of Psychedelics Administered to Military Veterans in Naturalistic Retreat Settings

The acute effects of classic psychedelics on memory in humans

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up

Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression

Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial

Johns Hopkins study on psychedelics and Alzheimer’s

Note: In this show, we use “women” as shorthand for people with XX chromosomes. We understand sex and gender are more complex, and acknowledge the experiences we describe reach beyond that word.

See omnystudio.com/listener for privacy information.

Transcript

Click on a timestamp to play from that location

0:00.0

This show.

0:10.5

This show is not a substitute for professional medical advice, diagnosis, or treatment.

0:19.3

It is for informational purposes. Please consult your health care professional

0:23.5

with any medical questions. Welcome back to Decoding Women's Health. I'm Dr. Elizabeth

0:31.8

Pointer. Psychedelics come with all sorts of associations and preconceived notions.

0:42.8

Tech pros, wild partying, burning man, and the 1970s.

0:48.8

But in recent years, more research has emerged about the potential for psychedelics in clinical settings.

0:56.2

And finally, there are researchers studying these drugs with a specific audience in mind, women.

1:04.0

We really had never tried to properly understand women's biology in the context of many things, really,

1:10.1

but especially in areas like mental health and how we think about treating them.

1:12.5

And particularly as we came into this new world of psychedelics and psychedelic therapy. And for me, that was an incredibly stark, considering

1:17.8

that so many of the mechanisms that psychedelics work by, have so much synergy with the mechanisms

1:23.9

of female biology. That's Dr. Grace Blessed Hopley.

1:28.9

She's a neuroscientist and research associate at King's College London.

1:33.8

She's also the chief scientific officer at a biotech company in the UK focused on psychiatric

1:39.9

and neurologic disorders and the founder of Hystallica, an organization that focuses on psychedelics

1:47.4

and female biology. Much of her academic research focused on cannabinoids, but her background as an

1:54.8

Army Reserve officer and her work with military veterans led her to the field of psychedelics research. She believes that psychedelics can be

2:04.1

powerful tools for helping people living with depression and post-traumatic stress disorder,

2:09.7

which is commonly referred to as PTSD. And she's seen firsthand how these treatments can be

2:16.1

helpful for people from all different walks of life in dealing with mental and physical health challenges.

2:24.9

How did you first get interested in the therapeutic benefits of psychedelics?

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