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Nature Podcast

CureVac disappoints in COVID vaccine trial

Nature Podcast

podcast@nature.com

Science, Technology, News

4.5893 Ratings

🗓️ 18 June 2021

⏱️ 16 minutes

🧾️ Download transcript

Summary

After a slew of wildly successful vaccine trials, this week marked a more underwhelming result. The third mRNA vaccine to complete phase three trials, developed by CureVac, is just 47% effective at staving off disease according to preliminary data. This is a stark contrast with previous mRNA vaccines from Moderna and Pfizer BioNtec which returned around twice that efficacy in their trials. In this episode of Coronapod, we ask why the CureVac vaccine has faltered, and what this might mean for the future of the pandemic and mRNA vaccine development.


News: CureVac COVID vaccine let-down spotlights mRNA design challenges

News Feature: How COVID unlocked the power of RNA vaccines


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Transcript

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0:58.1

help.com. Welcome to CoronaPod. In this show, we're going to bring you nature's take on the latest

1:09.4

COVID-19 developments.

1:11.7

And we'll be speaking to experts around the world about research during the pandemic.

1:18.0

We're entering a new era now. We have new COVID strategies. There's some new unknowns, and we've got a

1:24.0

vaccine.

1:30.4

Hello and welcome to CoronaPod.

1:34.7

I'm Noah Baker, and joining me this week is Friend of the Nature podcast, Aili Dolgan.

1:35.3

Ailey, how are you?

1:37.4

Good. Thanks for calling me up, Noah.

1:42.4

So we're going to talk about yet another vaccine trial this week that's just come out.

1:46.5

It's from CureVAC. But this one stands out because it has not delivered amazing results in the way that we've become a bit of custom to. ALE, can you

1:52.9

tell me a little bit about what's recently come out from CureVac? Yeah, I think at this point,

1:56.8

everyone just kind of waits on things to move through phase three and read out and then you just

...

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