Costly mistakes plague 49ers in first loss of 2025 NFL Season

49ers Talk: A San Francisco 49ers Podcast

NBC Sports Bay Area

Nfl, Football, Matt Maiocco, San Francisco 49ers, Sports

4.6 • 988 Ratings

🗓️ 29 September 2025

⏱️ 40 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

An afternoon of errors resulted in the 49ers' first loss of the 2025 NFL season Sunday against the Jacksonville Jaguars. Despite a second-half comeback attempt, San Francisco couldn't overcome its four turnovers. Brock Purdy's looked shaky in his return from injury after missing the last two weeks with turf toe. Matt Maiocco and Jennifer Lee Chan discuss how a subpar performance from all three phases contributed to the 49ers' first defeat. Matt and Jennifer also address the curious postgame exchange between 49ers defensive coordinator Robert Saleh and Jaguars coach Liam Coen as the topic of sign-stealing could be a season-long storyline.

Transcript

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0:00.0	Savings. Big O savings.
0:03.5	Get up to $120 in savings and select Michelin Tires with installation purchase.
0:09.0	Plus, zero interest it paid in full within 12 or six months.
0:13.1	Big O Tires, the team you trust.
0:19.5	It was an equal opportunity loss for the 49ers on Sunday.
0:23.6	Brock Purdy had a rough day in his return to the starting lineup.
0:26.6	The offense turned the ball over four times.
0:28.6	The defense could not stop the run and did not lay a finger on the quarterback.
0:33.6	And special teams reverted back to its 2024 form.
0:36.6	The result was a disastrous loss to the Jacksonville Jaguars at Levi Stadium on Sunday in week four.
0:43.9	And now the 49ers have a quick turnaround to face one of their division rivals on Thursday night.
0:48.8	Jennifer Lee Chan and I will break it all down on this episode of 49ers talk coming at you right now.
0:55.3	Welcome to another episode of 49ers talk coming at you right now welcome to another episode of 49ers talk on nbc sports bay area dot com introducing your hosts matt mayoko and
1:03.3	jennifer lee chan all right drive away knowing you got the best deal on the road with big
1:08.0	o tires low price guarantee check out this week's specials and set an appointment at bigotires.com. Big O'Tires, the team you trust. I'm Matt. She's Jennifer,
1:20.0	and Jennifer was out there at Levi Stadium to witness firsthand this 49ers 2621 loss to the Jacksonville Jaguars.
1:29.9	And Jennifer, I would assume there probably weren't a whole lot of happy guys in that locker room.
1:35.1	No, no.
1:35.9	I think the one thing that is a saving grace about this one is that they have only a few days before they have to turn around,
1:41.3	go to Los Angeles and play a really tough Los Angeles Rams game.
1:45.2	So they all talked about how, hey, we can't dwell. We can't link her. That was Kyle Shanahan's message to
1:50.1	the team after the game. We got to move on. We got to start preparing for the Rams.
	...

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